Genetic differences in susceptibility to two-stage skin carcinogenesis have been known for many years. Studies of genetic crosses of sensitive DBA/2 with resistant C57BL/6 mice suggested that multiple autosomal genes determine the sensitivity of these mice to 12-O-tetradecanoylphorbol-13-acetate (TPA) skin tumor promotion. Previous studies mapped one promotion susceptibility locus, Psl1, to dis...

This study was performed to evaluate the clinical utility of the measurement of the expression of telomerase enzyme (the catalytic subunit of the complex hTERT) and of the chromosomal analysis of urine by multicolor fluorescence in situ hybridization (M-FISH) assay for the detection of bladder cancer and its recurrence. These results were compared with those afforded by urine cytology, hematuri...

Purpose: To correlate sonographic findings of fetal developmental abnormalities resulting from chromosomal aberrations and structural anomalies in 2nd trimester. Design: Cross-sectional study. Setting: Tertiary care centre. Patients and methods: Amid the reporting period from August 2007 to July 2014, prenatal fetal anomaly diagnosis in 9524 fetuses/babies were inspected and contrasted with pos...

To gain a better understanding of chromosomal aberrations in direct correlation with histology, we studied tumor material from 35 patients (36 regions) with primary prostate carcinoma by nonisotopic in situ hybridization. Nine biotinylated DNA probes were used on serial paraffin sections (centromer-specific probes for X, Y, 1, 7, 8, 10, 17, and 18, and a telomer-specific probe for 1p; ONCOR). O...

OBJECTIVE To assess the possible role of Doppler ultrasound assessment of ductus venosus blood flow in screening for chromosomal abnormalities at 10-14 weeks of gestation. METHODS Ductus venosus flow velocity waveforms were obtained immediately before fetal karyotyping in 486 consecutive singleton pregnancies at 10-14 weeks of gestation. All cases were screened for chromosomal defects by a co...

A close correlation between the cytocidal effects of arsenic trioxide (ATO) and aquaporin-9 (AQP9) expression levels has been proposed, yet detailed studies are still needed to confirm this association. Thus, in the present study, the correlation between the expression levels of AQP9 and sensitivity to ATO was investigated using two acute promyelocytic leukemia (APL) cell lines, NB4 and HT93A, ...

The sea louse Caligus rogercresseyi is a marine ectoparasite that constitutes one of the major threats to salmon farming industry, where primary control strategy use delousing drugs through immersion treatments. emergence pharmacological resistance in this copepodid species has previously been described using transcriptome data. However, molecular mechanisms underlying chromosome rearrangements...

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Agricultural soils are increasingly becoming sinks for wide number of hazardous contaminants which ultimately result in pollution. Plant bioassays, because of their sensitivity and affordability, have been recommended as first-tier assays which enable the detection of contaminants. The present study involves genotoxicity of four soil samples collected from different regions of Amritsar employin...