Trypsin-Giemsa banding studies on T cell leukemias induced in Robertsonian translocation mice by dimethylbenz[a]anthracene and Moloney leukemia virus show a trisomy of chromosome 15 even in cases in which chromosome 15 has undergone centromeric fusion with chromosomes 1, 5, or 6. These results suggest that the duplication of gene(s) located on chromosome 15 is of critical importance for murine ...

BACKGROUND The most frequently observed major consequences of ionizing radiation are chromosomal lesions and cancers, although the entire genome may be affected. Owing to its haploid status and absence of recombination, the human Y chromosome is an ideal candidate to be assessed for possible genetic alterations induced by ionizing radiation. We studied the human Y chromosome in 390 males from t...

HE male determining influence of the autosomes on sex differentiation T in Drosophila melanogaster was proven by BRIDGES in 1921 with the discovery of triploid intersexes. He found that individuals with two X chromosomes, as in diploid females, and three of each autosome (3A) develop intersexually. BRIDGES concluded that sex is determined by an interplay of female determining genes located prin...

INTRODUCTION Crusted or Norwegian scabies is an infectious skin dermatopathology usually associated with an underlying immunodeficiency condition. It is caused when the mite Sarcoptes scabiei infects the skin, and the immune system is unable to control its spread, leading to a massive hyperinfestation with a simultaneous inflammatory and hyperkeratotic reaction. This is the first report of a no...

The conservative "character of cell reproduction is predicated on the replication of the genetic material and the precise distribution of the products to the daughter cells. The grouping of many genetic units in few chromosomes creates problems in our visualization of the reproductive mechanism as it simplifies the mechanism itself. The evidence of genetics informs us that at least some of the ...

Populus (poplar) and Salix (willow) are sister genera in the Salicaceae family. In both lineages extant species are predominantly diploid. Genome analysis previously revealed that the two lineages originated from a common tetraploid ancestor. In this study, we conducted a syntenic comparison of the corresponding 19 chromosome members of the poplar and willow genomes. Our observations revealed t...

Minichromosome maintenance (MCM) proteins are essential eukaryotic DNA replication factors. The binding of MCMs to chromatin oscillates in conjunction with progress through the mitotic cell cycle. This oscillation is thought to play an important role in coupling DNA replication to mitosis and limiting chromosome duplication to once per cell cycle. The coupling of DNA replication to mitosis is a...

BACKGROUND 9p duplication is a structural chromosome abnormality, described in more than 150 patients to date. In most cases the duplicated segment was derived from a parent being a reciprocal translocation carrier. However, about 15 cases with de novo 9p duplication have been reported previously. Clinically, this condition is characterized by mental retardation, short stature, developmental de...

Most land plants are now known to be ancient polyploids that have rediploidized. Diploidization involves many changes in genome organization ultimately restore bivalent chromosome pairing and disomic inheritance, resolve dosage other issues caused by duplication. In this review, we discuss the nature of polyploidy its impact on behavior. We also provide an overview two major largely independent...

A case of a 27 year old male with a duplication of part of the long arm of chromosome 22 (22q11.2-q13.1) together with a pericentric inversion of the same chromosome is reported. Particular phenotypic features of note include absence of speech, persistent self-injury, lack of daily living skills, colobomata, and very poor vision. Similarities between this case and other case reports of duplicat...