Nigella damascena seed is characterized by the presence of the major alkaloid, damascenine and its related metabolites. To our knowledge, no detailed subchronic toxicological assessment of damascenine (DA) has been reported. The present study evaluated the potential toxicity of DA in vivo after sub-chronic intraperitoneal (i.p) administration in mice and in vitro following human erythrocyte hem...

Mutations producing beta-thalassemia reach individual gene frequencies greater than .01 in malarial-endemic regions because beta-thalassemia trait individuals have increased genetic fitness over that of normal individuals. Exon 3 of the beta-globin gene has been relatively spared as a site of common beta-thalassemia mutations. Frameshifts caused by the loss of a single nucleotide and nonsense m...

This review details the known health effects of arsine as well as the existing theories on the mechanism by which arsine exerts its toxic effect and conditions of occupational exposure to this gas. Exposure to arsine in occupational settings occurs mostly in the chemical and metallurgical industries when nascent hydrogen reacts with metallic arsenic or arsenic compounds. The available data indi...

Accurate and fast prediction of the hemodynamics artificial pump-lung is critical in design process. In this study, a comprehensive computational framework, including sliding mesh method, coupled free flow porous media model, hemolysis [Formula: see text] shear stress transport turbulence solution algorithms, introduced to accurately predict velocity field, pressure heads, hemolysis. The framew...

BACKGROUND To investigate the incidence and time course of hemolysis and its clinical effects following transurethral resection of the prostate (TURP) using distilled water as the irrigant. METHODS Between March 1996 and April 1997, 39 patients who underwent TURP due to benign prostatic hyperplasia (BPH) were randomly included in this study. The levels of plasma hemoglobin, haptoglobin and se...

Sickle cell disease (SCD) is an autosomal recessive disorder in the gene encoding the β-chain of hemoglobin. Deoxygenation causes the mutant hemoglobin S to polymerize, resulting in rigid, adherent red blood cells that are entrapped in the microcirculation and hemolyze. Cardinal features include severe painful crises and episodic acute lung injury, called acute chest syndrome. This population, ...

scorpion bite is a common health problem in many parts of the world, including the iran’s tropics. there are thousands of cases and a number of deaths due to scorpion bite every year in the country. the present study aims to provide further data regarding the details, complications and outcomes of scorpion bite cases referring to razi hospital, ahwaz, from march 2011 to april 2012. a total of 2...

Hemagglutination and hemolytic titrations of antisera using red cells to which antigens have been conjugated with bis(diazo)benzidine have been used as a measure of antibody activities (1--4) in this laboratory. Hemagglutination and immune hemolysis fitrations have comparable sensitivities. Immune hemolysis, however, can be modified to give a high degree of precision (5). Both methods have been...