conclusions these findings indicate that telbivudine, used in both monotherapy and combination therapy, improves the renal function of patients with chb. the improvements are particularly significant in patients at high renal risk. patients and methods this study included 336 chinese chb patients, who were selected from outpatients in tongji hospital. 44, 122, 66, 58, and 46 of these patients h...

background it has been found that itpase deficiency is caused by itpa gene polymorphisms. it was observed that itpa polymorphisms have impact on hematological changes, including hemoglobin (hb)-decline during treatment of chronic hepatitis c (chc) patients with pegylated-interferon (peg-ifn) plus ribavirin (rbv). conclusions in patients with chc, who were treated with peg-ifn plus rbv, hb-decli...

background hepatitis b virus (hbv) is among the leading causes of liver cirrhosis worldwide. predictors of cirrhosis in iranian chronic hepatitis b (chb) patients are yet to be clearly identified. objectives evaluating the predictive factors of liver cirrhosis in chb. patients and methods a longitudinal study was conducted during 1995 - 2014 on all chb patients who were referred to tehran hepat...

conclusions nx-dcp correlated positively with fibrosis stage and could discriminate well between hcv-related patients with or without significant fibrosis. moreover, nx-dcp had a similar predictive ability to the abovementioned models, and thereby could be a new noninvasive prediction tool for fibrosis. results increase in serum nx-dcp was significantly related to increase in fibrosis stage (p ...

conclusions this study showed that cccdna can be detected in the plasma specimen of 17.9% of iranian treatment-naive patients with chronic hepatitis b infection. therefore, designing prospective studies focusing on the detection of cccdna in these patients would provide more information. results the mean (sd) age of the patients was 41.1 ± 12.4 years (range, 20 - 62 years). from a total of 106 ...

results in a group of adult patients with chb, anxa2 values were far higher than those of the control group (p = 0.001). when we assessed anxa2 levels based on fibrosis stages, serum anxa2 levels of patients with early stage fibrosis (stages 1 - 3) were significantly higher than those of patients with advanced stage fibrosis (stages 4 - 5; p = 0.001). patients and methods this study included 17...

background to estimate the total annual cost due to chronic hepatitis b (chb)-related diseases imposed on each patient and his/her family in iran.   methods economic burden of chb-related diseases (chb, cirrhosis, and hepatocellular carcinoma) were examined. in this retrospective study, 100 iranian patients were identified to obtain their socioeconomic status, utilization (direct and indirect c...

background: with respect to the importance of hepatitis a in patients with chronic liver disease, current study was conducted with the aim of determining the prevalence of previous hepatitis a infection in hepatitis b virus carriers with different stages of liver disease. materials and methods: this was a cross sectional study. 283 hbsag positive subjects (including 118 inactive carriers, 144 p...

conclusions our study showed no correlation between rs12979860 and rs8099917 snps and chronic hbv infection. further studies, with larger sample sizes and different ethnicities, are necessary to validate our findings. objectives this study was carried-out to investigate the association of ifnl3 gene polymorphisms (rs12979860 and rs8099917) with hbv susceptibility, in chronic hbv-infected patien...

methods and materials: hepatitis b virus dna was detected by conventional pcr in some of the serum samples obtained from hbsag-positive chronic hepatitis b (chb) patients who were referred to health centers of shahrekord for routine monitoring of the disease. subsequently, using real-time pcr, the dna samples were used for genotyping and analysis of resistance to lamivudine. results: the dna wa...