Background and Objectives: Visceral leishmaniasis is a chronic disease in Africa and Asia, children under 5 years are affecting with L.infantum and older children and young adult with L.donovani Purpose of this study describes the characteristics of epidemiologic and clinicopathophysiologic and response to treatment of patient that affected in East Azarbaijan compared with other endemic areas ...

We report a patient with fever, progressive jaundice and abdominal distension, having marked pallor, icterus, ascites and hepatosplenomegaly. Investigations revealed pancytopenia and deranged liver functions. Doppler study revealed portal hypertension and endoscopy showed grade II oesophageal varices. Liver biopsy suggested leishmanial hepatitis and bone marrow demonstrated multiple LD bodies. ...

Visceral leishmaniasis is a chronic parasitic disease associated with severe immune dysfunction. Treatment options are limited to relatively toxic drugs, and there is no vaccine for humans available. Hence, there is an urgent need to better understand immune responses following infection with Leishmania species by studying animal models of disease and clinical samples from patients. Here, we re...

A retrospective study was carried out to evaluate skin diseases associated with Chronic Granulomatous Inflammation at Pakistan Institute of Medical Sciences (PIMS) over a period of six months. There were a total of 249 skin biopsies in this period, among which 14.8 % cases were diagnosed as lesions associated with chronic granulomatous inflammation. Among these cutaneous leishmaniasis constitut...

Leishmaniasis is a Neglected Tropical Diseases caused by protozoan parasites of the genus Leishmania. It major health problem in many tropical and subtropical regions world can produce three different clinical manifestations, among which cutaneous leishmaniasis has higher incidence than other forms. There are no recognized reliable means chemoprophylaxis or vaccination against infections with f...

A long-term follow-up of at least 10 years or until death of 44 patients taking part in a controlled prospective trial of prednisolone therapy in hepatitis B antigen negative chronic active hepatitis (lupoid hepatitis) has been performed at the Royal Free Hospital, London. Patients presenting between 1963 and 1967 were randomly allocated into control and treatment groups. Ten year life table su...

BACKGROUND Cutaneous leishmaniasis is a chronic, infectious disease caused by protozoa of the genus leishmania. The incidence of this disease is high in Brazil, with 19,746 new cases having been detected in 2008. The presence of amastigotes in the cytoplasm of histiocytes constitutes diagnosis of the disease; however, their presence is rarely found in late lesions, making histological diagnosis...

Background: Atopic dermatitis is the most common chronic inflammatory dermatitis, due to immunological disorders. Patients with atopic dermatitis are prone to infectious diseases including bacterial infections. On the other hand, atopy may be protective against helminthes parasites. The objective of this study was to compare the frequency and clinical presentations of cutaneous leishmaniasis in...

BACKGROUND Leishmaniasis is an infectious disease endemic today in many areas of South America. METHODOLOGY We discovered morphologic and molecular evidence of ancient infections in 4 female skulls in the archaeological cemetery of Coyo Oriente, in the desert of San Pedro de Atacama, Northern Chile. The boney facial lesions visible in the skulls could have been caused by a number of chronic i...

LEISHMANIASIS HAS SEVERAL CLINICAL FORMS self-healing or chronic cutaneous leishmaniasis or post-kala-azar dermal leishmaniasis; mucosal leishmaniasis; visceral leishmaniasis (VL), which is fatal if left untreated. The epidemiology and clinical features of VL vary greatly due to the interaction of multiple factors including parasite strains, vectors, host genetics, and the environment. Human im...