Infections due to nontypeable Haemophilus influenzae result in enormous global morbidity in two clinical settings: otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease (COPD). Recurrent otitis media affects up to 20% of children and results in hearing loss, delays in speech and language development and, in developing countries, chronic s...

Background: Chronic suppurative otitis media is a common problem in our part of the world and few end up with intracranial complication. Brain abscess, meningitis and lateral sinus thrombosis are the most common intracranial complications. Emergency Multi-specialty Intervention can prevent mortality. Aim: The objective of the study is to determine various types of intracranial complications aff...

CONTEXT Tympanostomy tube placement is the most common ambulatory surgery performed on children in the United States. OBJECTIVES The goal of this study was to synthesize evidence for the effectiveness of tympanostomy tubes in children with chronic otitis media with effusion and recurrent acute otitis media. DATA SOURCES Searches were conducted in Medline, the Cochrane Central Trials Registr...

BACKGROUND AND OBJECTIVES The aim of our study was to evaluate postoperative mastoid aeration according to the preoperative middle ear disease and investigate the factors affecting it. SUBJECTS AND METHODS We retrospectively reviewed the high-resolution computed tomography (CT) scans of temporal bones that were taken 1 year after surgery. The postoperative mastoid aeration was evaluated accor...

UNLABELLED The equivalent ear canal volume ranges from 0.3 ml to 1.0 ml in children and from 0.65 to 1.75 ml in adults. In subjects with chronic otitis media these values can be different, according to the disease status. AIM To study the equivalent ear canal volume in 52 ears of patients with chronic otitis media with and without active infection. STUDY DESIGN Clinical prospective with tra...

OBJECTIVE Biofilms have been shown to play a major role in the pathogenesis of otolaryngologic infections. However, very limited studies have been undertaken to demonstrate the presence of biofilms in tissues from patients with chronic otitis media (COM) with or without cholesteatoma. Our objective is to study the presence of biofilms in humans with chronic suppurative and nonsuppurative otitis...

Otitis media is often preceded by a viral upper respiratory tract infection that causes Eustachian tube obstruction, negative middle ear pressure, and accumulation of fluid in the normally air-filled space of the middle ear. Acute otitis media (AOM) is defined as the presence of fluid in the middle ear with signs and symptoms of an acute infection, such as fever and ear pain. Otitis media with ...

High-mobility group box 1 (HMGB1) is a nuclear non-histone protein, playing a critical role as a mediator between innate and acquired immunity; when released extracellularly, it coordinates the cellular stress response (under necrosis, bacterial lipopolysaccharide stimulation) and acts as an inflammatory marker and cytokine. The aim of the study was to demonstrate whether HMGB1 is over-expresse...

UNLABELLED Bone destruction in chronic otitis media with cholesteatoma is a common phenomenon. Expanding growth of cholesteatoma in the middle ear causes ischemia of the mucosa and bones with granulation tissue production. THE AIM OF THIS STUDY was to assess the expression and distribution of the key regulators of bone destruction: osteoprotegerin (OPG), Receptor Activator for Nuclear Factor ...