BACKGROUND Chronic spontaneous urticaria (CSU) is a common, debilitating disease that is frequently resistant to standard therapy. Omalizumab, anti-immunoglobulin-E humanized monclonal antibody, was recently shown to be effective in treating resistant CSU. OBJECTIVES To investigated the treatment of CSU with omalizumab in Israel. METHODS We conducted a multicenter retrospective analysis of ...

In spite of being an old disease and apparently easy to diagnose, chronic spontaneous urticaria (CSU) is still perceived as an uncontrollable and difficult to manage disease. The perception of the patient is that his/her condition is not well understood and that is suffering from a disorder with hidden causes that doctors are not able to tackle. Sometimes patients go through a number of clinici...

Results Serology for hepatitis B was found to be positive in 8 patients (3.38%) in the acute spontaneous urticaria group, in 9 patients (5.35%) in the chronic spontaneous urticaria group and in 5 subjects (2.27%) in the control group. Antibodies to HCV were identified in 3 patients (1.27%) with acute spontaneous urticaria, in 4 patients with chronic spontaneous urticaria (2.38%) and in one subj...

There is a lack of large, randomized, double-blind studies that address antihistamine updosing for chronic spontaneous urticaria (CSU). The objective of this systematic review is to explore and analyse available data to provide clinical evidence for the efficacy of antihistamine updosing. We searched the literature in Medline, Scopus, Google Scholar, Embase, Web of Science and Cochrane database...

Background: Autologous serum skin test (ASST) evaluates the presence of any serum histamine-releasing factors and histamine-releasing autoantibodies. Autologous serum therapy (AST) is a therapy in which repeated injections of autologous serum are administered intramuscularly for treatment of chronicspontaneous urticaria (CSU). The aim of this study is to evaluate the advantages and compare the ...

Chronic spontaneous urticaria (CSU) is a very common skin condition that causes considerable suffering and is often poorly responsive to drug treatment regimens. Most clinicians accept that multiple factors play a role in the aetiology of CSU, but there is a widespread reluctance to accept a significant role for 'mindbody' factors, despite a large number of clinical reports and studies over man...