2,4,6-Trichlorophenol (2,4,6-TCP) is a common chemical intermediate and a by-product of water chlorination and combustion processes, and is a priority pollutant of the aquatic environment in many countries. Although information on the toxicity of 2,4,6-TCP is available, there is a lack of information on the predicted no-effect concentration (PNEC) of 2,4,6-TCP, mainly due to the shortage of chr...

BACKGROUND Risk assessment of chemicals and other agents must be accurate to protect health. We analyse the determinants of a sensitive chronic toxicity study, risk assessment's most important test. Manufacturers originally generate data on the properties of a molecule, and if government approval is needed to market it, laws globally require toxicity data to be generated using Test Guidelines (...

The use of mind altering drugs has become a major characteristic of American social behavior, and in our complex technological society is is unlikely that man will ever be able to eliminate his desire or need for "artificial paradises" as a means of coping with the stresses of daily existence. Unfortunately, when individuals use drugs, many also tend to abuse them with subsequent disruption of ...

Salicylate toxicity continues to be encountered commonly in emergency medicine. This article portrays the signs and symptoms of salicylate toxicity, reviews the erratic absorption and elimination kinetics, describes the devastating physiologic effects of overdose, and illustrates the potentially subtle manifestations of chronic aspirin toxicity.

Introduction: Rasaushadhies (metal and mineral) preparations are unique that include Bhasma, herbo-mineral Kupipakwa rasayana hold a significant place in Ayurvedic pharmaceutics. Nearly 70 % of formulations combination one or more metallic/mineral with several herbs which have supporting role improving efficacy, relieving symptoms the disease to achieve long healthy life. Shilasindur is contain...

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♦Corresponding Author: Maher Soliman, MD Oncology Department, Faculty of Medicine, Alexandria University, Alexandria 21526, Alexandria, Egypt Tel: (+2) 03-4848280 Fax: (+2) 03-4848280 E-mail: [email protected] Abstract Background: Radiation-induced lung toxicity is an important dose-limiting toxicity in lung cancer radiotherapy, for which there are no generally accepted predictive fa...

Multifocal osteonecrosis is a rare disease; chronic use of corticosteroids is considered the main risk factor. Patients with chronic renal failure can develop aluminum toxicity, which can lead to osteomalacia and encephalopathy. An association between osteonecrosis and aluminum toxicity has been reported among patients with dialytic renal insufficiency. Occupational exposure to aluminum rarely ...

PURPOSE OF REVIEW Ketamine misuse and abuse is on the increase. This review focuses on recent studies on ketamine toxicity in recreational users and possible implications for the use of ketamine in chronic pain therapy. RECENT FINDINGS Urological toxicity, hepatotoxicity and cognitive deficits are all reported as adverse effects of the recreational use of ketamine. Urological toxicity and hep...

Two 19 year old patients with juvenile chronic arthritis developed liver toxicity during treatment with sulphasalazine. A significant increase in the levels of liver enzymes in serum samples was noticed in relation to the initiation of treatment in one patient and to the increase in dose in the second. The enzymes returned to normal levels 14 days after the drug had been stopped. A rechallenge ...