The hematopoietic syndrome is anticipated when a dose of radiation greater than 100 cGy is received. The resulting clinical situation is life-threatening because of opportunistic infections and gradual decline in immune competency due to irradiation. Because of evidence of a possible immunomodulatory role for cimetidine, an antagonist of histamine H2 receptors, we studied the effects of thi...

Forty-four patients with chronic duodenal ulceration were allocated randomly to either long-term maintenance treatment with cimetidine or proximal gastric vagotomy. All were followed up both clinically and endoscopically for periods of one to four years. The rate of recurrence of ulcer during and after medical treatment was 54% while after surgery it was 10%. One patient developed severe allerg...

Preoperative cimetidine 300 mg or ranitidh~e in 50 and 100 mg doses were administered intramuscularly to 120 patients in a randomized double-blind study. The volume and pH of gastric aspirate samples obtained after tracheal intubation and before extabation were measured. The pH of gastric aspirate was higher Jbllowing ranitidine 100 mg than ranitidine 50 mg or cimetidine 300 mg at both intubati...

The cardiovascular effects of i.v. cimetidine 200 mg or ranitidine 50 mg were investigated in a double-blind cross-over study of 20 critically ill patients in an intensive therapy unit. Both agents caused transient decreases in mean arterial pressure and systemic vascular resistance, although there was no significant change in heart rate, cardiac output, central venous pressure, pulmonary arter...

This double blind, double dummy study compares the rate of healing of erosive reflux oesophagitis, assessed endoscopically, with four and eight weeks treatment using omeprazole or cimetidine, and the effect of four and eight weeks treatment of reflux oesophagitis with omeprazole or cimetidine on reflux symptoms, microscopic healing, and in a subgroup of patients, oesophageal pH measurements. Om...

A sample of 16 patients had pentagastrin stimulation studies performed before starting a 12 week course of cimetidine, and again 12 hours after completing the course. Basal and pentagastrin stimulated intrinsic factor secretion was assayed in 13 patients. There was no significant difference in the pattern of secretion after 12 weeks' treatment with cimetidine. The basal and peak acid outputs of...

The new H2-receptor antagonist, ranitidine, has been compared with cimetidine and metiamide as an inhibitor of gastric acid secretion in the dog. All three compounds were effective both intravenously or by mouth in inhibiting secretion induced by histamine, pentagastrin, or bethanechol. This inhibition was mainly attributable to a reduction in the volume of secretion, although there was also a ...

Cimetidine is effective drugs on male reproductive system by its effect semen characteristic or parameters such as sperm motility, morphology and count, also cimetidine sexual hormones, were testosterone, FSH LH. In this investigation, 20 rats randomly classified into two groups, Control group(G1): This group contain 10 receiving normal saline group( G2): 100mg/kg. B.W. from group, during the p...

Aerobic composting is widely used worldwide as a natural process for handling human waste. Such waste often contains pharmaceutical residues from consumption, yet their impact on has not been studied. The aim of this study to investigate the antihistamine cimetidine (10 mg/kg, 100 mg/kg) aerobic feces. key results show that 10 mg/kg accelerates temperature increase and moisture removal substrat...