This research presents a dual-perspective, or bipartite view of teleology (i.e . purpose) and uses it to criticize qualitative models of cardiovascular systems in a manner that highlights the relationships between circulatory topology, behavior and function . The Bipartite Teleology Model (BTM) attributes 'purposefulness' to both steady-state and regulatory behavior thereby providing a split-le...

A 26-year-old woman was referred to an Emergency Department because of common flu-like syndrome with hemodynamic collapse. In Intensive Care Unit (ICU), she was diagnosed as a probable septic shock. But despite treatment her condition rapidly deteriorated during the subsequent hours. Diagnosis of cardiogenic shock was established. Mechanical circulatory support was inserted into the patient. Sh...

Background & Aim: Free radicals play a crucial role in the development of tissue damage in various human diseases such as cancer, aging, neurodegenerative disease, malaria and arteriosclerosis, and pathological events in living organisms. Antioxidants may have an important role in the prevention of these diseases. The aim of this study is to evaluate potency of scavenging of DPPH free radicals ...

One of the career areas included in the field of Biomedical Engineering is the application of engineering system analysis: physiological modelling, simulation and control. This paper describes a Virtual Laboratory for the analysis and the study of Human circulatory system. The Virtual Laboratory is based on the compilation of several mathematical models described in the literature. Presented ap...

the circulatory blood volume (oligaemia) is the most important factor in the production of wound shock, and that circulatory collapse occurs if a patient's effective blood volume is reduced below 70 per cent of normal. Grant and Reeve conclude that the most valuable signs in determining the degree of reduction in blood volume are the amount of tissue damage, and the systolic blood pressure. The...

IT HAS BEEN XaEt'ORTED that, when administered alone, the hvo clinically available narcotic antagonists, nalorphine hydrochloride (Nalline) 1-7 and levallorphan tartrate, 8-1~ have respiratory and circulatory effects similar to those of narcotics. When a third potent narcotic antagonist, naloxone hydrochloride, became available for experimental use, it seemed worthwhile to compare the respirato...

PURPOSE To review the physiology of cardiac output regulation by the peripheral vasculature. This will enable the clinician to understand and manage the complex circulatory changes in various forms of shock, and in other common altered circulatory states encountered in anaesthetic practice. SOURCE Articles were obtained from a Medline review (1966 to present; search terms: shock, venous retur...

OBJECTIVE To determine whether continuous systemic perfusion is of effective use when establishing primary repair of the aortic obstruction and associated cardiac malformations. METHODS Since 1991, 56 infants have undergone reconstruction of interrupted (in 28) or coarctated (in 28) aorta, concomitantly with closure of ventricular septal defects in 37, and repair of other malformations in the...

Results The major indication for circulatory support therapy was cardiogenic shock, followed by refractory cardiac arrest, arrhythmic storm, and support of high-risk interventions. Median duration of circulatory support was 3 days, maximum 62 days. The all-cause 30-day mortality in our group was 34.5%; in the subgroup of patients with severe refractory cardiogenic shock the 30-day mortality was...