A working model for the action of superantigens (SAg) is that they are simple proteins having binding sites for both MHC class II molecules and the V beta domain of the TCR. Binding of a SAg to both molecules cross-links the TCR, inducing a biologic response. In this study, we have tested this working model using a SAg mimic consisting of a hybrid Ab bispecific for the murine MHC class II molec...

It has been proposed that self and protozoan-derived GPI anchors are natural ligands of CD1d. In this study, we investigated the ability of GPI anchors from Trypanosoma cruzi to bind to CD1d and mediate activation of NKT cells. We observed that GPI-anchored mucin-like glycoproteins (GPI mucins), glycoinositolphospholipids (GIPLs), and their phosphatidylinositol moieties bind to rCD1d and inhibi...

The cellular basis for allograft rejection derives from the strong T cell response to cells bearing foreign MHC. While it was originally assumed that alloreactive T cells focus their recognition on the polymorphic residues that differ between syngeneic and allogeneic MHC molecules, studies with MHC class I-restricted CTL have shown that MHC-bound peptides play a critical role in allorecognition...

Addressing the problems in College English reading, writing and translation teaching, study adopts "condensation-expansion" "AB double Texts" based on PAD Class teaching model, which solves traditional teaching. This includes three parts: guiding ideology, mode, operating methods of "condensation-expansion AB text" writing, It mainly addresses long-standing imbalanced objectives, educational or...

Amplifiers are among the most commonly used circuits in electronics, performing a variety of functions wide range electronic systems. Depending on application and design, each amplifier generates waste heat. For power amplifiers that operate at low efficiency high output power, amount wasted energy can be significant. This paper presents an harvesting system based thermoelectric generators tran...

Class AB differential amplifiers using composite BiCMOS and bipolar transistors are introduced. Their utilization for the implementation of low voltage (+-1.65V) operational amplifiers with high slew rate and rail to rail common mode input voltage range is discussed.

We consider an electronic model for realizing the spin Bose-metal SBM phase on a two-leg triangular strip—a spin liquid phase found by Sheng et al. Phys. Rev. B 79, 205112 2009 in a spin-1/2 model with ring exchanges. The SBM can be viewed as a “C1S2” Mott insulator of electrons where the overall charge transporting mode is gapped out. We start from a two-band “C2S2” metal and consider extended...