Racecadotril, an enkephalinase inhibitor, was subjected to hydrolysis (acidic and alkaline), oxidation, photolysis and thermal stress, as per ICH specified conditions. The drug showed extensive degradation under acidic, basic hydrolysis and oxidative stress conditions whereas, it was stable under other stress conditions. A total of seven degradation products (DPs) were observed. The chromatogra...

Trimethoprim is a synthetic compound which arrests the step in bacterial purine synthesis immediately succeeding that interfered with by sulphonamides. Acting alone it inhibits the growth of a wide range of bacteria in generally much lower concentrations than sulphonamides. Its action with a sulphonamide is strongly synergic and bactericidal.Studies are described of suitable cultural conditions...

The recent availability of robots specifically designed for use in laboratories raises the question 'Is there a place for robots in clinical chemistry laboratories?' Some direct experience with the Zymark robot over the last 18 months suggests that the answer to this question is equivocal and it is my intention to elaborate on this lheme. Over the last 15 to 20 years there has been a steady inc...

Cephalexin, 7

There is an introductory chapter on the use of the microscope and then successive chapters on examination of the sputum, the urine, the blood, gastric and duodenal contents, the faeces, animal parasites, pus and other body fluids, miscellaneous examinations including divers subjects such as the pregnancy tests and diagnosis of rabies, sero-diagnosis, bacteriological methods, and vaccines and sk...

Audits are part of the continuous quality improvement process and one of the key elements of clinical governance. Laboratory-based clinical audits are concerned primarily with the everyday aspects of laboratory services and are a means of providing feedback to the users of the laboratory and its staff. They involve measuring the performance of laboratory services against established standards. ...