Background: Calcineurin inhibitors like tacrolimus and pimecrolimus are new modality of treatment of localized vitiligo. Objective: To compare the effectiveness and side effects of 1% pimecrolimus cream in comparison with 0.05% clobetasol propionate cream as a treatment of localized type of vitiligo. Patients and Methods: Fifty two patients with localized vitiligo were included in this single, ...

EN: erythema nodosum ENM: erythema nodosum migrans INTRODUCTION Erythema nodosum migrans (ENM) is a rare clinical variant of erythema nodosum (EN). It is a septal panniculitis characterized by asymmetrical, mildly tender, nodules that migrate over time. Fever, sore throat, or arthralgias may also accompany the cutaneous manifestations of the disease; however, this is uncommon. The treatment of ...

A 57-year-old African American woman came to our dermatology clinic to reestablish care. She had a long history of plaque psoriasis involving her trunk and extremities. More recently, she had developed progressive hair loss, which her previous physician had attributed to the psoriasis. Before this visit, our patient had been treating her psoriasis with topical clobetasol and calcipotriene. A ph...

Lichen nitidus is an uncommon skin condition that is clinically characterized by the presence of pinpoint papules, which are usually asymptomatic, flesh colored, with a flat, shiny surface. The histopathologic feature of it is characteristic. We report a 30-year-old man with typical skin lesions of lichen nitidus confirmed with histopathology, who also had multiple palmar pits. Treatment ...

The most widely prescribed drugs for the treatment of a variety dermatoses are Topical corticosteroids (TC). These medications approved inflammatory and pruritic manifestations dermatologic disorders due to their powerful symptom-relieving impact. Clobetasol propionate (CP) is popular (TC) used relieve itching, redness, oedema caused by skin disorders. Anti-inflammatory, anti-pruritic, vasocons...

Thirty-nine patients (15 outpatients and 24 inpatients) with a variety of skin diseases affecting variable areas of the body surface were treated with clobetasol propionate ointment (Dermovate). Before and after treatment the adrenal response to an intramuscular injection of tetracosactrin was rested and additional 9 am plasma cortisol levels were measured at intervals during treatment. A satis...

INTRODUCTION Topical glucocorticoids (TG) are the most frequently prescribed drugs by dermatologists. Their clinical effectiveness in the treatment of psoriasis and atopic dermatitis is related to their vasoconstrictive, anti-inflammatory, immunosuppressive and anti-proliferative effects. Despite their benefit in the therapy of inflammatory diseases, TG are associated number of side effects tha...

A massive extravasation of pegylated-liposomal doxorubicin (Doxil) accidentally occurred, affecting the right forearm of a 54-year-old woman with metastatic ovarian cancer who was receiving an intravenous infusion of the drug. In accordance with the institutional guidelines for vesicant drugs, a corticosteroid preparation was immediately injected subcutaneously into the surrounding tissues. Clo...