The therapeutic efficacy of liposomal clofazimine (L-CLF) was studied in mice infected with Mycobacterium tuberculosis Erdman. Groups of mice were treated with either free clofazimine (F-CLF), L-CLF, or empty liposomes twice a week for five treatments beginning on day 1 (acute), day 21 (established), or day 90 (chronic) postinfection. One day after the last treatment, the numbers of CFU of M. t...

Acne agminata is an asymptomatic papulopustular eruption. This condition typically occurs in young adults. The eruption generally runs a self-limited course, but disfiguring scars can occur. Histological examination shows scattered dermal granulomas composed of epitheloid and some giant cells with central caseation. A variety of agents such as wide-spectrum antibiotics, oral steroids, dapsone, ...

A 26-year-old male vitiliginous patient presented with decreased visual acuity because of a central scotoma in the left eye with no significant retinal changes on fundus examination. In this case report, a diagnosis of possible drug-induced premaculopathy was made, and the drugs were withdrawn. On the follow-up, after 3 months, the visual acuity in the left eye gradually improved. Early suspici...

Pyoderma gangrenosum is characterized by a chronic, non-infectious, destructive ulcer which is mostly seen on distal lower extremities, but it can be found anywhere on body. We report an 18-year old man who developed keloids after healing of his ulcers. He was a known case of chronic relapsing pyoderma gangrenosum. His previous ulcers were used to heal leaving atrophic, cigarette-paper sc...

Multidrug therapy consisting of rifampicin, clofazimine and dapsone, was introduced to Trinidad and Tobago in January 1982. This was with slight modification of the WHO regimens. Since then 717 patients have completed multidrug therapy up to the end of December 1987. Of these, 272 patients have completed surveillance and have been discharged from clinic attendance. Thirty-four patients died bef...

Leprosy is a chronic granulomatous infection caused by the organism Mycobacterium leprae that primarily affects the skin and peripheral nerves. Leprosy has several distinct clinical presentations ranging from moderate to severe, with the extent of disease generally depending on the host's immune response to the infection. Treatment typically involves antimicrobials (eg, clofazimine, dapsone, ri...

Twenty years ago, dapsone resistance had become so widespread a phenomenon among both treated and untreated leprosy patients, that the achievements of leprosy control obtained during the preceding 30 years by large scale dapsone monotherapy were in serious jeopardy. To avert the further spread of dapsone resistance, immediate implementation of multidrug therapy (MDT) was recommended by the WHO ...