The 2014 outbreak of Ebola virus (EBOV) in Western Africa highlighted the need for anti-EBOV therapeutics. Clomiphene is a U.S. Food and Drug Administration (FDA)-approved drug that blocks EBOV entry and infection in cells and significantly protects EBOV-challenged mice. As provided, clomiphene is, approximately, a 60:40 mixture of two stereoisomers, enclomiphene and zuclomiphene. The pharmacok...

Polycystic ovary syndrome is a common cause of an ovulatory infertility. Drugs like Aromatase inhibitors, Human menopausal gonadotropin, used for ovulation induction. The aim this study was carried out to compare the therapeutic effects gonadotropin hormone versus oral ovarian stimulating agents. A prospective randomized controlled clinical trial in Salahdeen general hospital Tikrit from 1st Fe...

objective: recently the laparoscopic ovarian drilling (lod) has been used as a surgical treatment for ovulation in women with polycystic ovarian syndrome (pcos), although its mechanism and outcomes are still unclear. this study was undertaken to evaluate the in vitro fertilization (ivf)/intracytoplasmic sperm injection (icsi) outcomes in clomiphene-resistant women with pcos who were treated wit...

This study was conducted to see the effects of Clomiphene Citrate on fertility hormones estrogen, progesterone, LH, FSH in patients with infertility associated polycystic ovary syndrome. For this fifty infertile PCOS who were given treatment clomiphene citrate (50–150mg/day for 5 days). Ovarian response ovulation monitored by transvaginal ultrasonography and serum levels FSH, estrogen also esti...

While the effectiveness of clomiphene citrate in the treatment of oligo-ovulatory women has been demonstrated, its use in unexplained infertility remains controversial. In fact, expectant management, controlled ovarian stimulation plus intrauterine insemination and in vitro fertilization are among the possible treatments options for unexplained infertility. According to the most recent Cochrane...

BACKGROUND Poor ovarian response to controlled ovarian stimulation is one of the most important interest points in assisted reproduction. Mild ovarian stimulation seems to be preferable to high dose of FSH regimens in women with a history of poor ovarian response in previous protocol. Clomiphene citrate and letrozole alone or in combination with FSH have been used in mild ovarian stimulation pr...

INTRODUCTION This study was undertaken to compare between clomiphene citrate (CC) and gonadotropin-releasing hormone antagonist-based protocols in donor-recipient cycles in terms of parameters of ovarian stimulation and obstetric outcome. MATERIALS AND METHODS Two hundred and three fertile oocyte donors were stimulated using two different protocols: Clomiphene based (n = 103) and antagonist b...