Compared to conventional photon-based external beam radiation (PhXRT), carbon ion radiotherapy (CIRT) has superior dose distribution, higher linear energy transfer (LET), and a higher relative biological effectiveness (RBE). This enhanced RBE is driven by a unique DNA damage signature characterized by clustered lesions that overwhelm the DNA repair capacity of malignant cells. These physical an...

Previous research presented in numbers of studies strongly suggests that locating a cluster generates valuable benefits to clustered firms. These include better access suppliers and other scarce inputs, superior knowledge innovation, position from which build social network as well proximate successful competitors. Yet when the positive impact agglomeration clustering has been questioned on str...

The anatomical correlates of tactile and visual extinction with double simultaneous stimulation were investigated in a series of 159 patients with right brain damage caused by stroke. Forty six patients showed extinction (22 tactile, 14 visual, 10 tactile and visual). Over 50% of the patients with extinction had deep lesions, which were found in about 25% of the patients with visuospatial negle...

Senescent cells produce and secrete various bioactive molecules including interleukins, growth factors, matrix-degrading enzymes and reactive oxygen species (ROS). Thus, it has been proposed that senescent cells can damage their local environment, and a stimulatory effect on tumour cell growth and invasiveness has been documented. However, it was unknown what effect, if any, senescent cells hav...

It is now well-established that outcomes of radiotherapy depend on quality of radiation. A large body of experimental evidences suggests that high-LET (linear energy transfer) radiation or particle radiation has the ability to kill tumor cells more efficiently than low-LET photon beams such as X-rays and γ-rays [1,2]. The unique characteristics of particle beam, which includes precise dose dist...

INTRODUCTION Chemotherapy-related endothelial damage contributes to the early development of cardiovascular morbidity in testicular cancer patients. We aimed to identify relevant mechanisms of and search for candidate biomarkers for this endothelial damage. METHODS Human micro-vascular endothelial cells (HMEC-1) were exposed to bleomycin or cisplatin with untreated samples as control. 18k cDN...

We present a polynomial-time algorithm for c-planarity testing of clustered graphs with fixed plane embedding and such that every cluster induces a subgraph with at most two connected components.

Ultrasonic pulse-echo C-scan imaging is a widespread method for detecting and characterizing defects in fiber reinforced polymer composites. However, the accurate assessment of complex distributed damage cluster, like barely visible impact damage, multi-layer heterogeneous composites not straightforward. For reliably estimating remaining load carrying capacity and/or useful lifetime damaged com...