Mutations in CDKN2A have been found in sporadic cutaneous malignant (CMM), in familial CMM and in other syndromes associated with melanoma. In this study DNA was obtained from 207 individuals and five cell lines. There were 157 CMM patients and 50 healthy members of melanoma patients families. The CMM group included patients with one or two melanoma cases in the family, families with dysplastic...

Clavibacter michiganensis subsp. (Cmm), is a devastating bacterial disease agent causing wilt and canker in tomatoes. There no definitive solution to prevent yield losses by Cmm Moreover, there currently commercially successful resistant tomato cultivar on the market. Therefore, we aimed determine tolerance level of some accessions present study. For this purpose, screened seven representing fo...

This paper presents an exploratory case study on the SW-CMM (Capability Maturity Model for Software) Level 2 certification process by an offshore software development center, located in Brazil, belonging to Dell Computer Corporation. The objective of this paper is present the main Lessons Learned in this research. Also, it presented the importance and the impact in the inter-organizational rela...

The Software Engineering Institute (SEI) has developed several aids to help software organizations define, manage, and improve their software processes: The IDEALSM (initiate, diagnose, establish, act, and leverage) model for process improvement, appraisal methods that include assessments for internal process improvement and evaluations to select and monitor contractors, and the Capability Matu...

The purpose of this paper is to provide software measurements for implementation of the goals of the Requirements Management Key Process Area (KPA) of the Capability Maturity Model (CMM), and to ease the adoption of the KPA. The paper also provides practical guidance for people trying to implement the Requirements Management KPA. The CMM, developed by the Software Engineering Institute (SEI) is...

The Software Engineering Institute's (SEI) Capability Maturity Model (CMM) gets a lot of publicity. Given that the institute is funded by the US Department of Defense to the tune of tens of millions of dollars each year [1], this should come as no surprise=97 the folks at the SEI are the official process mavens of the military, and have the resources to spread the word about what they do. But, ...

are associated with high-dose intermittent UVR, and there are even types of CMM that are not related to sunlight [2]. The incidence of CMM is 4-19 per 100000 individuals in Europe [3], and many patients are younger than 40 years old. Hereditary factors that affect skin pigmentation, DNA repair efficacy, and immune response play a very important role in the pathogenesis of CMM. CMM is characteri...

This paper presents a novel and fast k-NN classifier that is based on a binary CMM (Correlation Matrix Memory) neural network. A robust encoding method is developed to meet CMM input requirements . A hardware implementation of the CMM is described, which gives over 200 times the speed of a current mid-range workstation, and is scaleable to very large problems. When tested on several benchmarks ...

Activation of neurons in the ventrolateral region of the periaqueductal gray (vlPAG) can elicit a decrease in renal sympathetic nerve activity and blood pressure. The present study investigated whether the vlPAG-evoked sympathoinhibitory response depends on neurons in the caudal midline medulla (CMM). In pentobarbital-anesthetized rats, activation of neurons in the vlPAG evoked a decrease in re...

Risk of cutaneous malignant melanoma (CMM) is increased in sun-exposed whites, particularly those with a pale complexion. This study was designed to investigate the relationship of the melanocortin-1 receptor (MC1R) genotype to CMM risk, controlled for pigmentation phenotype. We report the occurrence of five common MC1R variants in an Australian population-based sample of 460 individuals with f...