نتایج جستجو برای: cns relapse prophylaxis
تعداد نتایج: 167473 فیلتر نتایج به سال:
BACKGROUND Childhood acute lymphoblastic leukemia is the single most common childhood malignancy. Despite substantial improvements in therapy, cases in which relapse occurs are still more common than newly diagnosed cases of many other childhood cancers. The survival of patients who relapse despite improved therapy continues to be of interest. METHODS One thousand one hundred forty-four relap...
BACKGROUND Improvement in outcome of childhood high-risk (HR) ALL was sought with a very intensive Nordic protocol leaving most patients without CNS-RT. METHODS A total of 426 consecutive children entered the NOPHO-92 HR-ALL program. HR criteria included WBC > or =50 x 10(9)/L, CNS or testicular involvement, T-cell, lymphomatous features, t(9;22), t(4;11), or slow response. Of these, 152 chil...
Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report pediatric case ALK-positive ALCL with primary concomitant involvement bone and central nervous system (CNS); thereafter, literature review about CNS was conducted. According to analyze...
The aim of this study was to evaluate the relationship between cerebrospinal fluid (CSF) osteopontin (OPN) levels and central nervous system (CNS) involvement in children with a diagnosis of acute leukemia. The study sample consisted of 62 patients who had been diagnosed with acute leukemia. The control group consisted of 16 patients that had presented and had no malignant disease, CNS infectio...
Advancements in early diagnosis and the introduction of effective agents have improved the rates of response of aspergillosis to primary antifungal therapy. These changes allow the subsequent continuation of cytotoxic chemotherapy and/or performance of hematopoietic stem cell transplantation in an increasing number of patients with hematological malignancies. These developments have increased i...
Acute Promyelocytic Leukemia (APL) relapse in the central nervous system (CNS) can be isolated or associated with bone marrow relapse. Management of CNS APL remains a challenge. In this study, we identified an effective therapeutic regimen for CNS APL that consisted of single-reagent intravenous infusion with arsenic trioxide (ATO) preceded and accompanied by mannitol. Seventeen patients with i...
Introduction: A century-long history in 8-aminoquinolines, the only anti-malaria drug class preventing malaria relapse, has resulted approval of tafenoquine by U.S. Food and Drug Administration (FDA) Australian Therapeutic Goods (TGA) to date registration Brazil Thailand. Tafenoquine is an alternative anti-relapse treatment for vivax prophylaxis. It should not be given pregnancy, during lactati...
Central nervous system (CNS) relapse has been an obstacle to uniformly successful treatment of childhood acute lymphoblastic leukemia (ALL) for many years. We therefore intensified intrathecal chemotherapy (simultaneously administered methotrexate, hydrocortisone, and cytarabine) for 165 consecutive children with newly diagnosed ALL enrolled in Total Therapy Study XIIIA from December 1991 to Au...
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