BACKGROUND: Pressure ulcers/injuries (PU/Is) negatively affect patients by causing pain and increasing morbidity mortality risks. Care teams have a heightened sense of awareness the condition may feel confident in their ability to appropriately identify manage PU/Is, but potential for, consequences of, misdiagnosis always should be considered. PURPOSE: The purpose this compendium is describe il...

Summary Inflammasomes and the interleukin (IL)-1 family of cytokines are key mediators both inflammation immunothrombosis. responsible for release pro-inflammatory IL-1β IL-18, as well releasing tissue factor (TF), a pivotal initiator extrinsic coagulation cascade. Uncontrolled production inflammatory results in what is known “cytokine storm” leading to hyperinflammatory disease. Cytokine storm...

Coronavirus disease (COVID-19), caused by Sars-Cov-2, affects several cell types, including the vascular endothelium, which can lead to immunological phenomena and coagulopathies with systemic lesions. Thus, objective was describe, through a bibliographic review, endothelial dysfunction induced coronavirus. The data collected in this study suggest that lesion of endothelium coronavirus leads de...

Nowadays the comorbid pathology of liver cirrhosis and atrial fibrillation has been widely discussed reported in literature light recent findings from study effectiveness safety anticoagulants this category patients. The review is devoted to summarizing existing data on course these diseases point view impact bleeding thrombosis quality life mortality patients possibility using new methods diag...

Massive splenic infarction (MSI) is a rare phenomenon that results from compromised blood flow to more than half of the spleen. Causes of MSI include hematological disorders, coagulopathies, infection, and embolization, and, rarely, MSI is spontaneous. The mainstay of treatment is splenectomy. We report the case of a 50-year-old man with a history of renal transplant who presented with diffuse ...

Spontaneous ventral spinal epidural hematomas are extremely rare in children and clinically recognized by the appearance of acute asymmetric focal motor and sensory involvement. In infants, the initial presenting symptoms are very non-specific and irritability is often the only initial manifestation. Appearance of other neurological signs may be delayed up to hours or even days later. In the ab...

In certain cases such as cancer patients or patients with coagulopathies, the venous thrombosis is a frequent complication that is associated with the implantation of central venous catheters. However, it is uncommon in other contexts, such as acute myocardial infarction without complications in its fifth day of evolution, after being treated with platelet inhibitors in addition to the initial ...

Intravenous administration of hematin is effective in the treatment of acute exacerbations of the inducible porphyrias. In the course of such treatment, coagulopathies have occurred that are characterized by prolongation of prothrombin time, partial thromboplastin time, and formation of fibrin split products. In experiments in vitro with normal human plasma, we observed that hematin and protopo...