INTRODUCTION The early application of fibrinogen could potentially reverse haemodilution-induced coagulopathy, although the impact of varying concentrations of fibrinogen to reverse dilutional coagulopathy has not been studied in vivo. We postulated that fibrinogen concentration is correlated with blood loss in a pig model of coagulopathy with blunt liver injury. METHODS Coagulopathy was indu...

BACKGROUND The 20-min whole blood clotting test (WBCT20) is widely used for the identification of coagulopathy in snake envenoming, but its performance in practice has not been evaluated. AIM We aimed to investigate the diagnostic utility of the WBCT20 for coagulopathy in Russell's viper envenoming. DESIGN Prospective observational study. METHODS Adult patients with snake envenoming were ...

Coronavirus disease 2019 (COVID-19) is a viral infection that, in severe course, leads to the development of cytokine storm, systemic inflammatory response and coagulopathy. Unlike other sepsis-associated disseminated intravascular coagulopathy, COVID-19 induced coagulopathy realized mainly thrombosis. Researchers around world are currently developing adequate diagnostic, monitoring anticoagula...

INTRODUCTION Acute traumatic coagulopathy has been associated with shock and tissue injury, and may be mediated via activation of the protein C pathway. Patients with acute traumatic coagulopathy have prolonged PT and PTT, and decreased activity of factors V and VIII; they are also hypocoagulable by thromboelastometry (ROTEM) and other viscoelastic assays. To test the etiology of this phenomeno...

0

We report a case of visual loss after the Pfizer-BioNTech mRNA coronavirus disease-2019 (COVID-19) vaccine injection. Two days COVID-19 vaccination, 56-year old female experienced in her right eye and she admitted to ophthalmology clinic. After detailed ophthalmologic examination investigations, including optical coherence tomography fundus fluorescein angiography, non-ischemic central retinal ...

BACKGROUND Acidosis, hypothermia, and coagulopathy were identified more than 20 years ago as a deadly triad for patients presenting with exsanguinating hemorrhage. This led to fundamental changes in initial management of severely injured patients. Despite major advances, hemorrhage remains a leading cause of early death in trauma patients. Recent studies report most severely injured patients to...

early prediction of ongoing hemorrhage may reduce mortality via the earlier delivery of blood products, adequate orientation of the patient in a dedicated highly specialized and trained infrastructure, and by earlier correction of acute traumatic coagulopathy. we identified 14 scores or algorithms developed for the prediction of ongoing hemorrhage and the need for massive transfusion in severe ...