We investigated the role of prostanoid-mediated pressor mechanisms in setting the level of blood pressure in renin-dependent and renin-independent models of hypertension in unanesthetized rats. Intravenous administration of a blocker of thromboxane A2/prostaglandin endoperoxide receptors, SQ29548 (2 mg/kg bolus injection plus 2 mg/kg/hr for 3 hours), reduced from 162 +/- 4 to 144 +/- 5 mm Hg (p...

Heart disease in pregnancy is the leading indirect cause of maternal mortality.1 Coarctation aorta a rare condition found pregnant mothers and they are at extremely high risk life-threatening or fetal events any given time. Management these should be done specialized maternity hospitals, under care multidisciplinary team. Anesthetists involved various stages management mothers, especially durin...

OBJECTIVE To report the timing of presentation and clinical profile of a cohort of fetuses with normal main cardiac connections but fetal echocardiographic signs suggestive of coarctation of the aorta. DESIGN Retrospective observational study. SETTING Tertiary fetal and paediatric cardiology centre. PATIENTS Between 1 January 1998 and 31 December 2002, 174 fetuses were studied, of whom 14...

Coarctation is a narrowing of the aorta located between the first brachiocephalic vessel and the aortic bifurcation. When isolated coarctation is associated with congestive heart failure, it is considered clinically important,2 but what is "important" when the child is asymptomatic? Shaddy et all use as an entrance criterion "hemodynamically significant native coarctation of the aorta" without ...

We contrasted in normotensive and hypertensive rats the effect of inhibition of nitric oxide synthesis on isometric tension development by aortic rings bathed in Krebs' bicarbonate buffer. NG-Nitro-L-arginine methyl ester (L-NAME) (3 x 10(-4) mol/L) increased tension (82 +/- 11% of the response to 120 mmol/L potassium chloride) in rings of thoracic aorta taken from hypertensive rats 7 to 14 day...

RATIONALE Coarctation of aorta in adulthood is usually complicated by other cardiovascular anomalies, posing great technical challenge for intervention. PATIENT CONCERNS Here, we report an extremely rare case of aortic arch coarctation combined with a poststenotic biloculated calcified aneurysm and hypoplastic left subclavian artery. INTERVENTIONS First, an extra-anatomic bypass was establi...

Coarctation of the aorta is a congenital cardiac malformation that can go undiagnosed until old age with only hypertension as a marker of its presence because clinical signs can be subtle and overlooked if a complete physical exam is not performed. We report the case of a 45 year-old women, diagnosed with severe coarctation of the aorta just distal to the left subclavian artery, with poststenot...

OBJECTIVES Coarctation of the aorta is one of the most common congenital heart defects. Its diagnosis may be difficult in the presence of a patent ductus arteriosus, of other complex defects or of a poor echocardiographic window. We sought to demonstrate that the carotid-subclavian artery index (CSA index) and the isthmus-descending aorta ratio (I/D ratio), two recently described echocardiograp...

oarctation of the aorta is a discrete narrowing of the aorta, the main blood vessel carrying oxygen-rich blood from the heart to the body, causing an obstruction to blood flow. Coarctation is a common congenital heart defect, an abnormality in the structure of the aorta that is present at birth or shortly after birth. It may be identified in infants or older children or adults and successfully ...

Introduction Combination of acute aortic dissection associated with aortic coarctation in pediatric population is extremely rare. We are presenting a 12-year-old patient with these two conditions who was successfully treated with two-stage surgery. Case Outline A boy with no trauma history was admitted for chest pain. The diagnosis of acute aortic dissection associated with aortic coarctation w...