نتایج جستجو برای: codon 72 polymorphism

تعداد نتایج: 213974  

Journal: :Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2004
Shu-Pin Huang Wen-Jeng Wu Wun-Shaing Wayne Chang Ming-Tsang Wu Yun-Yun Chen Yun-Ju Chen Chia-Cheng Yu Tony T Wu Ying-Huei Lee Jong-Khing Huang Chun-Hsiung Huang

The tumor suppressor gene p53 and its downstream effector p21 are thought to play major roles in the development of human malignancy. Polymorphic variants of p53 at codon 72, and p21 at codon 31, have been found to be associated with cancer susceptibility, but few studies have investigated their effect on prostate cancer risk. In this case-control study, we investigated the association of p53 c...

Journal: :Asian Pacific journal of cancer prevention : APJCP 2012
Ting Xu Zi-Cheng Xu Qin Zou Bin Yu Xin-En Huang

OBJECTIVE Individual studies of the associations between P53 codon 72 polymorphism (rs1042522) and bladder cancer susceptibility have shown inconclusive results. To derive a more precise estimation of the relationship, we performed this systemic review and meta-analysis based on 15 publications. METHODS We used odds ratios (ORs) with 95% confidence intervals (CIs) to assess the strength of th...

Journal: :International journal of clinical and experimental medicine 2015
Xin Wang Li-Ran Hao Kai Yue

BACKGROUND The polymorphism of TP53 codon 72, a transversion of G to C (Arg to Pro), has been demonstrated to be associated with the risk for lung cancer. However, individual studies conducted in Chinese have provided conflicting and inconclusive findings. Thus, we performed a meta-analysis by pooling all currently available case-control studies to estimate the effect of TP53 codon 72 Arg/Pro p...

Journal: :Molecular vision 2002
Moulinath Acharya Sayan Mitra Arijit Mukhopadhyay Mita Khan Susanta Roychoudhury Kunal Ray

PURPOSE Glaucoma is a complex neurodegenerative disorder of the eye. Primary Open Angle Glaucoma (POAG) is the most common type, accounting for over half of the total cases. Recently, a significant difference in the distribution of the codon 72 polymorphism of the tumor suppressor gene p53 between control subjects and POAG patients of Chinese origin (p=0.00782) was demonstrated. The proline res...

2016
Ying Chan Baosheng Zhu Hongguo Jiang Jinman Zhang Ying Luo Wenru Tang

To evaluate the association of the TP53 codon 72 (rs 1042522) alone or in combination with HDM2 SNP309 (rs 2279744) polymorphisms with human infertility and IVF outcome, we collected 1450 infertility women undergoing their first controlled ovarian stimulation for IVF treatment and 250 fertile controls in the case-control study. Frequencies, distribution, interaction of genes, and correlation wi...

Journal: :The Journal of biological chemistry 2005
Xiaoxian Li Patrick Dumont Anthony Della Pietra Cory Shetler Maureen E Murphy

In addition to a common polymorphism at codon 72, the p53 tumor suppressor gene also contains a rare single nucleotide polymorphism at amino acid 47. Wild type p53 encodes proline at this residue, but in <5% of African Americans, this amino acid is serine. Notably, phosphorylation of the adjacent serine 46 by the proline-directed kinase p38 MAPK is known to greatly enhance the ability of p53 to...

Journal: :Oncology reports 2008
Laura Boldrini Silvia Gisfredi Silvia Ursino Marco Lucchi Giordana Greco Alfredo Mussi Gabriella Fontanini

Mutations of the p53 gene represent the most common genetic alterations in human cancer. Several reports have focused on p53 polymorphisms as risk factors in lung cancer, in particular at codon 72 of exon 4, encoding either an arginine (Arg72R) or a proline (Pro72P) amino acid. Polymorphisms at codon 72 of the p53 gene were determined using a PCR-RFLP-based method. We analysed the relationship ...

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