The fast-growing bacterium Mycobacterium smegmatis is a model mycobacterial system, a nonpathogenic soil bacterium that nonetheless shares many features with the pathogenic Mycobacterium tuberculosis, the causative agent of tuberculosis. The study of M. smegmatis is expected to shed light on mechanisms of mycobacterial growth and complex lipid metabolism, and provides a tractable system for ant...

background and aims: the ectodomain of matrix protein of influenza virus is a weak immunogen that is highly conserved among all subtypes of influenza a virus. tandem repeats of these genes along with linker were used to enhance immunogenicity of m2e protein and so it can be served as a universal vaccine in both humans and livestock. materials and methods: in this study, the sequences of extra-d...

conclusions based on the location of detected rccs in the structure of hbv proteins, it was found that these rccs may have a critical role in correct folding of hbv proteins and can be considered as drug targets. the results of this study provide new and deep perspectives about structure of hbv proteins for further researches and designing new drugs for treatment of hbv. results the pfam search...

In contrast to conventional vaccines, DNA and other subunit vaccines exclusively utilize host cell molecules for transcription and translation of proteins. The adenine plus thymine content of Plasmodium falciparum gene sequences (approximately 80%) is much greater than that of Homo sapiens (approximately 59%); consequently, codon usage is markedly different. We hypothesized that modifying codon...

The article offers a solution to the problem of fast and efficient recognition coronavirus genus. For this purpose, authors apply virus genome targeting method based on use sufficiently short conserved N-gene nucleocapsid protein. Comparison codon frequency distributions in analyzed set 67 prototypical strains corresponding subgenus allows us recognize genus coronavirus. This paper proposes opt...