The agglutinins towards Bacillus abortus found in the blood serum of new-born calves are obtained from the mother through the colostrum. Calves at birth, unfed, are without agglutinins. The problem of the production of agglutinins by the fetus in whose tissues Bacillus abortus has multiplied and which is subsequently expelled prematurely is not touched by these observations.

INTRODUCTION Cardiac surgery involves cardiopulmonary bypass during which the core temperature is generally lowered to hypothermic levels. Patients presenting for cardiac surgery are sometimes reported to have cold or warm autoantibodies at the time of blood screening. It is known that cold agglutinins may cause potentially life-threatening haemolysis, intracoronary haemagglutination leading to...

1. The absorption of typhus sera (human or antityphus horse serum) with Proteus X-19 removes only the Proteus agglutinins, leaving the Rickettsia agglutinins intact. 2. The absorption of typhus sera with Mexican Rickettsiae removes the agglutinins for both the Rickettsia and Proteus X-19. 3. While normal or formalinized Rickettsiae are not agglutinated by anti-Proteus serum, these organisms-whe...

In the current study, we wished to determine if the V regions encoding the naturally occurring anti-i/I Cold Agglutinins (anti-i/I CA) differ from pathogenic anti-i/I CA that are exclusively encoded by the VH4.21 gene. After EBV transformation of B lymphocytes, we generated one anti-I secreting clone from each of two individuals; clone 4G (individual CM, PBL) and clone Sp1 (individual SC, splee...

Cold agglutinin immunohaemolytic anaemia (CAIA) responds poorly to standard treatment. We report a case of marginal zone lymphoma complicated by CAIA that responded to rituximab after failing to respond to corticosteroids and chlorambucil.

Cold agglutinin disease (CAgD) is a type of autoimmune hemolytic anemia which generally occurs in adults and is characterized by the presence of IgM antibodies directed against polysaccharide antigens on red blood cell surface. A 16-year-old male, having clinical picture of sepsis and anemia, presented to the Emergency Department of our Institute in an Hemodynamically unstable condition. Invest...

1. Agglutinins are present in the blood of patients suffering from lobar pneumonia during some stage of the disease in a large percentage (73.8 per cent.) of the cases due to pneumococci belonging in groups I, II, and IV. 2. In most very severe and fatal cases agglutinins cannot be demonstrated, and it is probable that their absence during the later days of the disease may have unfavorable prog...

Two serologically distinct antibodies directed against different antigenic sites on the Group A carbohydrate were detected in human sera by agglutination techniques. Agglutinins with A-variant specificity were demonstrable by the direct agglutination of purified A-variant cell walls, whereas indirect Coombs-type agglutinins with Group A specificity were demonstrable with Group A cell walls. Sel...