background of the study: colorectal cancer (crc) which is the third most diagnosed cancer throughout the world is steadily rising in the asian countries with the incidence rates mimicking the western counterparts. the pre-neoplastic nature of the transitional mucosa (tm) adjoining crc lacks conclusive evidence so far. pertaining to this, the study of the mucus layer, the functional component of...

primary colorectal lymphoma (pcl) is a rare condition that accounts for a small percentage of all gastrointestinal (gi) malignancies. there are several reports in the literature regarding the most common features of pcl. however, primary lymphoma in the rectosigmoid junction has been rarely reported. our case was a 67-year-old male who presented with non-specific symptoms of bowel obstruction w...

the aim of this study was to test the therapeutic efficacy of sodium alginate in a rat model of trinitrobenzene sulfonic acid (tnbs)-induced inflammatory bowel disease. this experiment was carried out using 77 sprague-dawley rats which were divided into six groups; normal, control, prophylactic, therapeutic and two experimental groups. rats were sacrificed 1, 2, 3 and 6 weeks after colitis indu...

The effective delivery and colonization of probiotics are recommended for therapeutic interventions during colitis, the efficacy which is hampered by abnormally colonized Enterobacteriaceae at pathological sites. To improve probiotics, a calcium tungstate microgel (CTM)-based oral probiotic system proposed herein. CTM can selectively disrupt ecological niche occupied expanded colitis to facilit...

Research shows that topically active infliximab therapy may be efficacious in the treatment of inflammatory bowel disease (IBD) with expected fewer side effects related to systemic exposure. Oral administration site-specific delivery could enable such therapy. In present study, was incorporated a sugar glass matrix (IFX-I) for additional stability and compounding flexibility after which IFX-I c...