Colorectal cancer (CRC) is one of the most common cancers and one of the leading causes of cancer death in the Western world. The disease arises from the accumulation of mutations in oncogenes, tumor suppressor genes and mismatch repair genes during progression from normal colon epithelium to adenoma and metastatic carcinoma. The majority of colorectal cancers arise in sporadic form. About one-...

Colorectal carcinoma (CRC) is one of the most common malignant neoplasms with significant morbidity and mortality worldwide. Cancer stem cell hypotheses have gathered attention to their molecular progression. CD44, a marker, reported be more concentrated in premalignant cells. We aimed study prognostic therapeutic utility CD 44 colorectal adenoma low/high-grade dysplasia its correlation clinico...

•CRC remains a leading cause of cancer-related deaths globally, despite improvements in management.•Mutations the BRAF gene are seen 10% patients with mCRC, particularly due to V600E substitution.•V600E substitution is marker poor prognosis and reduced response treatment mCRC.•Combination involving MAPK pathway blockade has shown promise for V600E-mutated mCRC.•Continued research needed further...

Recent studies from mouse mapping studies for cancer susceptibility have successfully led to the identification of a handful of susceptibility genes. Ptprj was identified as a strong candidate gene for mouse locus susceptibility to colorectal cancer 1, and one variant, rs1566734, showed evidence of preferential allelic imbalance in human colorectal tumors. Haplotypes in human PTPRJ have also be...

Background: Colorectal cancer (CRC) predominately affects adults over the age of 50, however it occasionally occurs in young patients. Case: This case observes presentation and management a 14-year-old African American male (AAM) who presented to emergency department with two-week history insidious onset RLQ abdominal pain. Evaluation suspected small bowel obstruction computed tomography raised...

OBJECTIVES To characterise the mRNA expression patterns of early and advanced stage colorectal adenocarcinomas of Malaysian patients. DESIGN Comparative expression analysis. SETTING AND PARTICIPANTS We performed a combination of annealing control primer (ACP)-based PCR and reverse transcription-quantitative real-time PCR for the identification of differentially expressed genes (DEGs) associ...

BACKGROUND The marked variability in age at onset of colorectal cancer (CRC) in patients with hereditary nonpolyposis colorectal cancer (HNPCC) makes management decisions difficult. Environmental factors governing the phenotypic variability of cancer-associated syndromes such as HNPCC have not been elucidated. METHODS We determined whether tobacco use would alter CRC risk in carriers of HNPCC...

PURPOSE Several researchers have suggested that the rs4779584 (15q13.3) polymorphism is associated with an increased risk of developing colorectal cancer (CRC). However, past results remain inconclusive. We addressed this controversy by performing a meta-analysis of the relationship between rs4779584 of GREM1-SCG5 and colorectal cancer. METHODS We selected 12 case-control studies involving 11...

Colorectal cancer (CRC) remains a major worldwide cause of cancer-related morbidity and mortality largely due to the insidious onset of the disease. The current clinical procedures utilized for disease diagnosis are invasive, unpleasant, and inconvenient; hence, the need for simple blood tests that could be used for the early detection of CRC. In this work, we have developed methods for glycopr...

Colorectal cancer (CRC) remains one of the deadliest malignancies worldwide despite recent progress in treatment strategies. Though immune checkpoint inhibition has proven effective for a number other tumors, it offers benefits only small group CRC patients with high microsatellite instability. In general, heterogenous cell groups tumor microenvironment are considered as major barrier unveiling...