1,223 ambulant patients with gonorrhoea were each treated with a single dose of eight tablets of cotrimoxazole. 1,069 patients were followed up (794 males and 275 females). Of these, only 46 (4%) failed to respond. Cotrimoxazole in the dosage used was well tolerated by all the patients, with very few side-effects. There was clear evidence that cotrimoxazole did not mask concomitant syphilitic i...

............................................................................................................................. ii Co-Authorship Statement ............................................................................................... iii Acknowledgments ............................................................................................................ iv Table of

Co-trimoxazole (Septrin, Wellcome) was prescribed in a dose of two tablets twice daily for the treatment of 10 patients with Donovanosis. All the patients responded well to this treatment, and the ulcers healed completely within 10 days in eight patients and within 14 days in the remaining two. Ten days' treatment with 40 tablets of co-trimoxazole is suggested as sufficient to treat Donovanosis...

eperisone hydrochloride is a skeletal muscle relaxant and paracetamol is cyclooxygenase inhibitor. these drugs in combination are used as antispasmodics. a simple, specific, precise and accurate method was developed, namely reverse phase high performance liquid chromatography for simultaneous estimation of eperisone hydrochloride and paracetamol in tablet dosage form. in rp-hplc method separati...

INTRODUCTION1, 2 In the last decade, interest in developing a combination of two or more Active Pharmaceutical Ingredients (API) in a single dosage form (bi-layer tablet) has increased in the pharmaceutical industry, promoting patient convenience and compliance. Bi-layer tablets can be a primary option to avoid chemical incompatibilities between APIS by physical separation, and to enable the de...

The combination of dextropropoxyphene and paracetamol, marketed as Distalgesic, once a popular analgesic, is now less commonly prescribed. Each tablet contains 32-5mg of dextropropoxyphene and 325mg of paracetamol. Overdoses with this preparation were common in the late seventies, though nowadays are rarely seen. ' Overdoses of as little as twenty tablets very often led to death within thirty m...

Executive Summary The lumacaftor and ivacaftor fixed dose combination oral tablet (OrkambiTM, Vertex Pharmaceuticals, Inc.) is the second Food and Drug Administration (FDA) approved member of a new pharmacologic class of drugs termed cystic fibrosis transmembrane conductance regulator (CFTR) modulators.[1] CFTR modulators target the underlying defect (reduced CFTR function) that causes disease ...

in this study, different derivative spectrophotometric methods are proposed for the simultaneous determination of chlorpheniramine maleate (cp), phenylephrine hcl (pe) and phenylpropanolamine hcl (pp) in their ternary mixtures and in pharmaceutical dosage forms. spectra of single component and ternary mixtures of various concentrations and combinations from zero- to fourth-derivation were obtai...

Concentrations of trimethoprim (TMP) and sulfamethoxazole (SMZ) in blood were determined in seven healthy volunteers after ingestion of 720 mg of TMP and 3,600 mg of SMZ (nine tablets of TMP-SMZ, 1:5 ratio) as a single oral dose. The mean levels of drug in blood achieved during the first 8 h after drug administration ranged from 6.12 to 8.32 mug/ml for TMP and 98 to 120 mug/ml for SMZ. These co...

Estradiol (E2) and drospirenone (DRSP) (Yasmin ®, Berlex), a combination estrogen–progestin birth control tablet, has been shown to be safe and effective as hormone replacement therapy in postmenopausal women while offering benefits in terms of improvements in blood pressure, lipid profiles, and body weight. Researchers enrolled 1,142 amenorrheic postmenopausal women in a multicenter, double-bl...