We identified a patient with severe inherited erythromelalgia secondary to an L858F mutation in the voltage-gated sodium channel Na(v)1.7. The patient reported severe ongoing foot pain, which was exquisitely sensitive to limb cooling. We confirmed this heat hypersensitivity using quantitative sensory testing. Additionally, we employed a novel perfusion imaging technique in a simple block design...

With the successful launch of Chandra and XMM/Newton X-ray space missions combined with the lower-energy band observations, time has arrived when careful comparison of thermal evolution theories of isolated neutron stars with observations will offer a better hope for distinguishing among various competing neutron star cooling theories. For instance, the latest theoretical and observational deve...

We propose and analyze a scheme to cool atoms in an optical lattice to ultralow temperatures within a Bloch band and away from commensurate filling. The protocol is inspired by ideas from dark-state laser cooling but replaces electronic states with motional levels and spontaneous emission of photons by emission of phonons into a Bose-Einstein condensate, in which the lattice is immersed. In our...

Combined annealing experiments and observations by transmission electron microscopy show that in natural pigeonite crystals antiphase domains coarsen approximately according to a rate law in which the tenth power of the average domain size is proportional to time. This result suggests that certain cations (possibly Ca(2+)) were segregated preferentially onto the antiphase boundaries. The domain...

This paper describes a platform for cooling microfluidic chips so as to freeze aqueous droplets flowing in oil. Using a whole-chip cooling chamber, we can control the ambient temperature surrounding a microfluidic chip and induce cooling and freezing inside the channels. When combined with a droplet generation and droplet docking chip, this platform allows for the facile freezing of droplets im...

This investigation deals with the combined effects of Navier slip, suction/injection, convective cooling and temperature dependent viscosity on an unsteady third grade fluid flow in a porous channel filled with saturated porous medium. The heat exchange with the ambient at the channel surfaces is assumed to obey Newton’s law of cooling. The model equations governing the flow system are solved u...