Normal hemostasis requires balanced regulation of prothrombotic and antithrombotic factors. Inherited alteration of factor V and prothrombin gene, the G20210A mutation, increases the resistance of factor V to degradation and booster production of prothrombin respectively. These alterations can increase hypercoagulability leading to thrombotic consequences. We aimed to assess the frequencies of ...

BACKGROUND AND OBJECTIVES The prothrombin G20210A mutation and factor V Leiden have been found to be associated with an increased risk of venous thrombosis, but the reported prevalences of the prothrombin gene variant both in the normal population and in patients with deep venous thrombosis (DVT) vary greatly in the literature. Moreover, the influence of oral contraceptives (OC) on thrombotic e...

In his original description of a patient with parahemophilia and his studies on the nature of the defect, Owren (1) proposed that the missing factor, proaccelerin (Factor V), was converted, in the presence of calcium, into a prothrombinconverting substance ("prothrombinase," Factor VI) by the action of tissue thromboplastin. Other investigators, notably Ware and Seegers (2) in a series of studi...

In his original description of a patient with parahemophilia and his studies on the nature of the defect, Owren (1) proposed that the missing factor, proaccelerin (Factor V), was converted, in the presence of calcium, into a prothrombinconverting substance ("prothrombinase," Factor VI) by the action of tissue thromboplastin. Other investigators, notably Ware and Seegers (2) in a series of studi...

AIMS To determine to what extent the Arg506 to Gln point mutation in the factor V gene and further genetic factors of thrombophilia affect the risk of porencephaly in neonates and infants. METHODS The Arg506 to Gln mutation, factor V, protein C, protein S, antithrombin, antiphospholipid antibodies and lipoprotein (a) (Lp(a)) were retrospectively measured in neonates and children with porencep...

Inherited thrombophilia has been implicated as a possible cause of recurrent pregnancy loss. Although numerous studies are available in literature, thrombophilia rate seems to vary from study to another. The aim of our study was to determine the frequency of FII Prothrombin (G20210A), Factor V Leiden (G1691A), as well as methyl tetrahydrofolate reductase (MTHFR C677T) polymorphisms, protein C, ...

A derivation of the classical jump rate I' for tracer diffusion aimed at a clear expression for the mass dependence of the frequency factor v is presented. The derivation is effected without using the usual collective normal coordinates which usually combine the masses in a complicated way. v depends explicitly on the mass of the surrounding host atoms (as well as on the tracer-atom mass) if th...

We perform transport measurements in high quality bilayer graphene pnp junctions with suspended top gates. At a magnetic field B = 0, we demonstrate band gap opening by an applied perpendicular electric field with an On/Off ratio up to 20,000 at 260 mK. Within the band gap, the conductance decreases exponentially by 3 orders of magnitude with increasing electric field and can be accounted for b...