INTRODUCTION .......................................................................................................... 123 MEASUREMENTS OF DIETARY BIOAVAILABILITY OF IRON ...................... 124 Earlier Methods .......................................................................................................... 124 Extrinsic Tag Method .....................................................

OBJECTIVE To evaluate the bioequivalence of50 mg cilostazol tablets manufactured locally (Citazol®) and originally (Pletaal®) in healthy Thai volunteers. MATERIAL AND METHOD An open-label, single dose, randomized, two-period, two-sequence, crossover study in 30 healthy volunteers. Each volunteer received a 50 mg cilostazol tablet of bothformulations with a washoutperiodofat least 14 days. Blo...

Linezolid is a new antimicrobial agent effective against drug-resistant gram-positive pathogens which are common causes of infections in hospitalized patients. Many such patients rely on the intravenous or enteral route for nutrition and drug administration. Therefore, the bioavailability of linezolid administered enterally in the presence of enteral feedings in hospitalized patients was examin...

Due to low cost, ease of administration, and lack need for trained personnel, the oral route is the most convenient and accessible way to design different medicines that could be simply consumed by patients. Regardless of the great benefits of this route, the main challenge in the bioavailability of oral medications is gastrointestinal instability. Nanotechnology is used to improve the solubili...

Pitavastatin is a BCS class II drug with low solubility and high permeability. So, the purpose of study was to develop characterize pitavastatin-loaded liposomes achieve sustained release by increasing as well bioavailability in treating hyperlipidemia. All formulations were prepared using ether injection method (EIM) determine effect three independent factors lecithin, cholesterol, chitosan/PE...

BACKGROUND Poor oral bioavailability is an important parameter accounting for the failure of the drug candidates. Approximately, 50% of developing drugs fail because of unfavorable oral bioavailability. In silico prediction of oral bioavailability (%F) based on physiochemical properties are highly needed. Although many computational models have been developed to predict oral bioavailability, th...

pioglitazone belongs to the thiazolidinedione (tzd) class of antidiabetic agents, with proven efficacy in increasing insulin sensitivity and in the treatment of type 2 diabetes mellitus in humans. pioglitazone has been proposed as a potential feed additive to reduce insulin resistance and consequently some of the metabolic disorders in transition cows. this study was aimed at determining the...

present study determines not only the total amounts of metals (cr, cu and pb) in superficial agricultural soil of sistan area in eastern iran, but also the chemical partitioning of these elements in seven statistically selected cases. the analysis was run for local soil, soil treated by non-contaminated organic, compost and chemical fertilizers as well as soil treated by metal-contaminated fert...

urban horticulture is of growing importance in developing and developed countries around the world; however, contamination of urban horticultural products can exceed the precautionary values, posing significant human health risks due to dietary exposure to high levels of the pollutants. in this study, samples of rhizosphere soil and corresponding vegetables have been collected from an urban gar...

Background: In this open-label, randomized, balanced, two-treatment, two-sequence, two-period, crossover, single-dose oral comparative pharmacokinetics study, the pharmacokinetics, safety, and tolerability of test product ‘ashwagandha (Withania somnifera)’ root extract sustained release capsule 300 mg (Prolanza™), each containing 15 withanolides (administered dose: 2×15 mg) was compared with th...