Remifentanil is a synthetic opioid with ultrafast elimination. Its pharmacokinetics after a one-minute infusion in children (age range 5 days 17 years) have been described by Kinder Ross et al. using modelindependent analysis [1]. The first objective of the present study was to obtain a compartmental model of remifentanil pharmacokinetics with the possible inclusion of covariates age and weight.

This paper describes a general approach to the compartmental modeling of nuclear data based on spectral analysis and statistical optimization. We utilize the renal physiology as test case and validate the method against both synthetic data and real measurements acquired during two micro-PET experiments with murine models.

Examples of Aggregate (Compartmental) Simulation Models 19 SimSmoke 19 University of Michigan Tobacco Prevalence and Health Effects Model 23 Tobacco Policy Model 24 Benefits of Smoking Cessation Outcome 25 Smoking-Attributable Morbidity, Mortality, and Economic Costs 25 Cancer Strategy Analysis and Validation Effect 26 Cancer Intervention and Surveillance Modeling Network (CISNET) 26 Examples o...

Regional Cerebral Blood Flow Estimated by TMXenon Inhalation • A method is described for estimating the clearance rate and fractional blood flow of the fast (gray matter) compartment of the brain from the first ten minutes of Xe clearance curves, following a one-minute inhalation. Computer-simulated data were used to test the adequacy of the two-compartmental model employed, and to evaluate the...

In biology and mathematics compartmental systems are frequently used. System identiica-tion of systems based on physical laws often involves parameter estimation. Before parameter estimation can take place, we have to examine whether the parameters are structurally iden-tiiable. In this paper we propose a test for the structural identiiability of linear mamillary compartmental systems. The meth...

The transfer functions of discrete-time SISO compartmental systems whose compartments are connected either in series or in parallel are characterized, and then the corresponding realization problem is studied. The obtained results are extended to the transfer matrix of N-periodic compartmental systems.