UNLABELLED To investigate the pain-modulatory effects of a local inflammatory stimulus on pain elsewhere in the body, capsaicin was applied topically to the forearm of 14 healthy female volunteers. Pressure-pain thresholds and sensitivity to sharpness were assessed on each side of the forehead twice per day during 48 hours of capsaicin treatment, and in the treated and contralateral forearm bef...

http://dx.doi.org/10.1016/j.pain.2014.06.005 0304-3959/ 2014 The Authors. Published by Elsevier B.V. on behalf of International Association for the Study of Pain. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/). ⇑ Corresponding author at: Aarhus University Hospital, Department of Neuroradiology, Center of Functionally Integrative ...

The clinical approach to complex regional pain syndrome (CRPS) is complicated by a lack of precision diagnostically, and a lack of evidence-based information for treatment. The vagaries of diagnosis were somewhat improved by the Orlando Conference (1993), where a consensus panel of experts developed a new taxonomy and criteria. Unfortunately the criteria can be based entirely on subjective grou...

Several publications and reports have recently advocated the use of intravenous ketamine infusions for the treatment of chronic pain. In Pain, Schwartzman and colleagues present the results of a randomised controlled trial where 19 patients with CRPS were treated with ketamine or placebo infusions [9]. The trial was stopped prematurely before half of the planned number of patients was included,...

BACKGROUND Movement accuracy is ensured by interaction between motor, somatosensory, and visual systems. In complex regional pain syndrome (CRPS), this interaction is disturbed. To explore CRPS patients' visual perception of actions, we investigated how these patients evaluate the applied force in observed hand actions of another person. METHODS Nineteen patients suffering from unilateral upp...

OBJECTIVE To report the initial and long-term outcome after an intensive exercise therapy program for childhood complex regional pain syndrome, type I (CRPS). DESIGN Prospective follow-up. SETTING A children's hospital. SUBJECTS We followed 103 children (87 girls; mean age = 13.0 years) with CRPS. Forty-nine subjects were followed for more than 2 years (mean = 5 years 3 months). INTERVE...

Evaluation of pain-induced changes in functional connectivity was performed in pediatric complex regional pain syndrome (CRPS) patients. High field functional magnetic resonance imaging was done in the symptomatic painful state and at follow up in the asymptomatic pain free/recovered state. Two types of connectivity alterations were defined: (1) Transient increases in functional connectivity th...

OBJECTIVE: The aim of this study was to investigate patients' knowledge of the most salient features of complex regional pain syndrome and to identify patient characteristics associated with the patients' level of knowledge. METHODS: Questionnaire interview of 101 patients with complex regional pain syndrome in Switzerland (mean age 54 years, 77% female). A questionnaire about patients' disease...

OBJECTIVE This is the fourth edition of diagnostic and treatment guidelines for complex regional pain syndrome (CRPS; aka reflex sympathetic dystrophy). METHODS Expert practitioners in each discipline traditionally utilized in the treatment of CRPS systematically reviewed the available and relevant literature; due to the paucity of levels 1 and 2 studies, less rigorous, preliminary research r...

The use of the term ‘neglect-like’ to characterise symptoms displayed by patients with complex regional pain syndrome (CRPS) [15] has proved to be provocative. It has provided the stimulus for an ever-increasing number of studies exploring spatial perception in affected patients, with calls for further related studies [20]. Although this work would undoubtedly be of interest, there are perhaps ...