Chronic myelogenous leukemia (CML) is characterized by the Philadelphia (Ph) chromosome, created by a reciprocal translocation t(9:22)(q34;q11) which forms the chimeric gene, BCR-ABL. Variant Ph chromosome translocations involving chromosomes other than 9 and 22 have been identified in 5-10% of CML cases. Four-way Ph chromosome translocations are an extremely rare event in myeloid malignancies ...

Despite the apparent similarity of the dexamethasone-receptor concentration in the rat liver and Novikoff hepatoma cytoplasms, the in vitro translocation of the dexamethasone-receptor complex into liver or hepatoma nuclei was three times greater from liver as compared to hepatoma cytosol; both cytosols showed an apparent saturation of nuclear receptor sites. Although the competitive interaction...

ewline"> Dispersion of heavy gases is considered to be more hazardous than the passive ones because it takes place more slowly. ...

The cytoplasmic surface of Sec61p is the binding site for the ribosome and has been proposed to interact with the signal recognition particle receptor during targeting of the ribosome nascent chain complex to the translocation channel. Point mutations in cytoplasmic loops six (L6) and eight (L8) of yeast Sec61p cause reductions in growth rates and defects in the translocation of nascent polypep...

Dear Editor, Hypoxia-inducible factor 1 (HIF1) is a master transcription factor that regulates the expression of hypoxia-inducible genes involved in erythropoiesis, vascular remodeling and glucose metabolism in response to hypoxia. Dysregulation of HIF1α has been heavily implicated in tumor progression. In this study, using exome sequencing, we identified a synonymous somatic variant of HIF1α (...

According to the World Health Organization (WHO) 2016 classification, acute promyelocytic leukemia (APL) is placed in category of AML with recurrent cytogenetic abnormalities. Cytogenetic confirmation reciprocal translocation t(15:17) essential criteria for diagnosis this entity. However, these tests may have a significant time delay and it usually characteristic morphology abnormal promyelocyt...

Gain of 8q24, harboring the avian myelocytomatosis viral oncogene homolog (MYC), is a frequent mutation in cancers. Although MYC is the usual suspect in these cancers, the role of other co-gained loci remains mostly unknown. We have recently found that MYC partners with the adjacent long non-coding RNA (lncRNA) plasmacytoma variant translocation 1 (PVT1), which stabilizes MYC protein and potent...

We report a novel chromosome translocation--t(2;5)(p23;q35) or its variant, t(2;5;13)(p23;q35;q12)--in 3 patients with peripheral T-cell lymphoma. All 3 were female children who had peripheral lymphadenopathy without organomegaly and underwent complete remission with or without chemotherapy. Their tumors were characterized histologically by predominant large cells, at times showing phagocytosis...