A new series of 3,4-dihydro-2H-1,4-benzoxazine derivatives, where various substituents were introduced into one of the geminal dimethyl groups at the 2 position, were synthesized and their potassium channel-activating activity was evaluated. Introduction of a hydroxyl group, as in compound 5, resulted in good solubility in water and a long duration of action compared with the parent compound 1....

In this paper, we address the challenging issue of multi-hop cooperative relaying over heterogeneous compound channels, where constituent channels can incorporate topographical variations and respective distribution changes (due to environmental factors). Existing methods in the literature address various issues pertinent to receiver design by assuming a homogeneous framework. Since real-time s...

Polar coding is a new technique introduced by Arıkan [1] based on a phenomenon called channel polarization. Polar codes are appealing as an error correction method since they are proved to achieve the symmetric capacity of any B-DMC using low complexity encoders and decoders, and their block error probability is shown to decrease exponentially in the square root of the block length. In fact, tw...

3 The purpose of this study was to quantify how vegetation influences the flow and sediment processes 4 relevant for the design and management of environmental compound channels. Therefore, we conducted a 5 two-year field investigation in a cohesive two-stage channel, focusing on the flow resistance and net 6 deposition in five sub-reaches with different floodplain vegetation conditions. In the...

Hydraulic engineering studies related to floods usually require the lateral distribution of flow velocity across the compound channel section, constituted by the main channel and the floodplain. 2D-Horizontal numerical models (such as the public domain software RMA2 of USACE) are now broadly accepted as an appropriate theoretical model to solve this problem. However, as in the majority of appli...

In areas that are occasionally inundated by floods, it is essential to know the quantity and density of vegetation that can be allowed while avoiding flooding beyond the intended floodplains. An unsteady flow model was developed for a channel with vegetated floodplains, to take into account the retention effects of the vegetated areas on flood wave conveyance. A one-dimensional (1D) unsteady fl...

Due to the short and bursty incoming messages, channel access activities in a wireless random access system are often fractional. The lack of frequent data support consequently makes it difficult for the receiver to estimate and track the time varying channel states with high precision. This paper investigates random multiple access communication over a compound wireless channel where channel r...

The quality of signal received at the destination depends upon the channel conditions and the propagation environment which can’t be always homogeneous. Weibull which is terrain specific distribution along with Gamma forms a versatile, flexible and multiparameter compound WeibullGamma heterogeneous channel model. Its closed expressions of Probability Density Function (PDF) and Cumulative Distri...

1. UK-78,282, a novel piperidine blocker of the T lymphocyte voltage-gated K+ channel, Kv1.3, was discovered by screening a large compound file using a high-throughput 86Rb efflux assay. This compound blocks Kv1.3 with a IC50 of approximately 200 nM and 1:1 stoichiometry. A closely related compound, CP-190,325, containing a benzyl moiety in place of the benzhydryl in UK-78,282, is significantly...

Coding with a single fixed rate may not achieve the maximum throughput of a compound channel if the transmitter only has access to channel state statistics. Superposition coding for broadcast channels can be employed to increase the throughput. We study the optimal rate allocation for finite level superposition coding to maximize the throughput. Results show 2-level superposition coding is adeq...