background: the purpose of this study was to evaluate the influence of three different luting protocols on shear bond strength of computer aided design/computer aided manufacturing (cad/cam) resin nanoceramic (rnc) material to dentin. materials and methods: in this in vitro study, 30 disks were milled from rnc blocks (lava ultimate/3m espe) with cad/cam technology. the disks were subsequently c...

Noroviruses (NoVs) are the most important viral pathogens that cause epidemic acute gastroenteritis. NoVs recognize human histo-blood group antigens (HBGAs) as receptors or attachment factors. The elucidation of crystal structures of the HBGA-binding interfaces of a number of human NoVs representing different HBGA binding patterns opens a new strategy for the development of antiviral compounds ...

Screening of ligand molecules for target protein using computer-aided docking is a critical step in rational drug discovery. Based on this circumstances ,we attempted to develop a virtual screening application system, named VSDK virtual Screening by Docking, which can function under windows and linux both platform. The predicted model of Cytochrome P450 (CYP26A1) was used for virtual screening ...

The drug development and discovery process are challenging, take 15 to 20 years, require approximately 1.5-2 billion dollars, from the critical selection of target molecule post-clinical market application. Several computational design methods identify optimize biologically lead compounds. Given complexity cost in recent computer-assisted (CADD) has spread over a broad spectrum. CADD support mo...