BACKGROUND Although childhood hyperactivity and conduct problems are associated with difficulties in adulthood, little is known about later service use or public expenditure costs in the UK. AIMS To describe the use of services and calculate recent (past 6 months) and early adulthood (since the age of 18 years) public expenditure costs incurred by young adults who had hyperactivity and/or con...

Individual heterogeneity exists in the onset and development of conduct problems, but theoretical claims about predictors and prognosis are often not consistent with the empirical findings. This study examined shape and outcomes of conduct problem trajectories in a Belgian population-based sample (N = 682; 49.5 % boys). Mothers reported on children's conduct problems across six waves (age 4-17)...

The development of conduct problems in childhood and adolescence is associated with adverse long-term outcomes, including psychiatric morbidity. Although genes constitute a proven factor of stability in conduct problems, less is known regarding their role in conduct problems' developmental course (i.e. systematic age changes, for instance linear increases or decreases).Mothers rated conduct pro...

Objective. To determine (1) the uniformity of disposition decisions made by clinicians working in Australian emergency departments (EDs) using vignettes describing patients presenting with deliberate self-harm or suicide risk; (2) factors associated with these decisions; (3) factors associated with confidence in these decisions. Methodology. We validated and distributed by email an online surve...

As science correspondent of the venerable British newspaper The Sunday Times between 1991 and 1994, Neville Hodgkinson persistently questioned the role of HIV in AIDS, the danger to heterosexuals and the growing dimensions of the AIDS epidemic in Africa. Now he has written the portentously entitled AIDS — The Failure of Contemporary Science (Fourth Estate), which describes and attempts to perpe...

LITERATURE REVIEW Antisocial behavior is inevitable in the course of development of children and is among the most common presenting complaints in the practice of child and adolescent psychiatry. Its relationship to psychopathology is complex (Robins et al, 1991; Raine, 1993; Wehby et al., 1993; Carey, 1994; Gureje et al., 1994; Rutter, 1996). Not all-antisocial behavior is pathological, theref...

Hepatic drug disposition is different in normal and diseased livers. Different disease types alter disposition differently. What are the responsible micromechanistic changes and how do they influence drug movement within the liver? We provide plausible, concrete answers for two compounds, diltiazem and sucrose, in normal livers and two different types of cirrhotic rat livers: chronic pretreatme...