background: in patients undergoing mechanical ventilation, mucus production and secretion is high as a result of the endotracheal tube. because endotracheal suction in these patients is essential, chest physiotherapy techniques such as expiratory rib cage compression before endotracheal suctioning can be used as a means to facilitate mobilizing and removing airway secretion and improving alveol...

there is no randomized study carried out in order to compare their pharmacokinetic parameters although midazolam, as a sedative, has been widely administered via continuous infusion as well as intermittent bolus doses in mechanically ventilated critically ill patients. we prospectively investigated the effect of these two principal methods on pharmacokinetic parameters in 23 of mentioned patien...

objectives the aim of this study was to study the incremental cost-effectiveness ratio associated with the use of heat and moisture exchangers (hme) filter to prevent vap compared with the heated humidifiers (hh) presently adopted by intensive care unit (icu) services within the brazilian healthcare unified system. patients and methods this study was a cost-effectiveness analysis (cea) comparin...

Background Many neonates admitted to Neonatal Intensive Care Unit (NICU) need mechanical ventilation for recovery. This study was designed to evaluate the short-term outcome of mechanically ventilated neonates admitted to NICU. <span style="fon...

With favourable and extensive experience in the neonatal intensive care unit (ICU) and the recent positive experience in the adult ICU, high-frequency ventilation has become a valuable alternative to conventional ventilation in acute lung injury. To arrive at this point, physicians' understanding of the characteristics and kinetics of acute lung injury had to become more distinct, and it was ne...

background : since the use of high concentrations of oxygen in infants may lead to chronic lung problems, using proper methods of care in infants under mechanical ventilation is one of the most important measures in nicu. this study aimed to investigate the effects of prone and supine positions on oxygenation (spo 2 ) in premature infants under mechanical ventilation and comparing infants’ oxyg...

The improvement in survival in premature infants associated with the evolution of mechanical ventilation has been accompanied by an increase in ventilator induced lung injury. High frequency ventilation has been shown to reduce the incidence of ventilator induced lung injury and hence chronic lung disease in the very low birth weight infant. The evolution in understanding how to best use high f...

background: application noninvasive ventilation in the patients with exacerbation of chronic obstructive pulmonary disease (copd) reduced mortality. this case-control study was designed to compare efficiency and outcome of non-invasive (niv) versus invasive positive pressure ventilation (ippv) in respiratory failure due to copd methods: the patients were assigned to niv or ippv intermittantly.t...

The inflammatory response is a primary mechanism in the pathogenesis of ventilator-induced lung injury. Autophagy is an essential, homeostatic process by which cells break down their own components. We explored the role of autophagy in the mechanisms of mechanical ventilation-induced lung inflammatory injury. Mice were subjected to low (7 ml/kg) or high (28 ml/kg) tidal volume ventilation for 2...