Early observations on the use of cycloserine have revealed disturbing emotional and neurological side effects attendant upon the administration of this new antibiotic to a number of patients with pulmonary tuberculosis.” 2, 3 Perhaps the most striking of these reactions have been epileptiform seizures, varying from slight tremors to grand mal convulsions. In most of these cases, the convulsions...

This study aims to investigate the effect of a methanol extract of Trachyspermum ammi (L.) as an antiepileptic agent. Tests were conducted with a singleand multiple-dosing schedule of Trachyspermum ammi (L.), using a strychnineinduced seizure model for epilepsy. Twenty-one animals were divided into three groups; control (vehicle), standard (diazepam) and test (Trachyspermum ammi (L.) extract). ...

Ictal hypoxemia has been reported in small series of cases and may contribute to sudden unexpected death in epilepsy (SUDEP). We sought to determine the incidence and severity of ictal hypoxemia in patients with localization-related epilepsy undergoing in-patient video-EEG telemetry. We examined whether seizure-associated oxygen desaturation was a consequence of hypoventilation and whether fact...

What is the long-term outlook for children with temporal lobe epilepsy and what factors influence this prognosis? Those questions have recently been answered in a series of papers1-4 from the National Centre for Children with Seizure Disorders at the Park Hospital, Oxford-a study remarkable not only for its penetrating analyses but also for the duration and completeness of follow-up. None of th...

Abrus precatorius which is commonly called as Indian licorice has been used for many centuries by traditional healers of Tanzania for the treatment of convulsions. The present work has been carried out to evaluate the anticonvulsant activity of the ethanolic extract (EE) of A. precatorius leaves against Pentylenetetrazole (PTZ), Picrotoxin and Maximal electroshock (MES) induced convulsions at t...

Ion channels play a central role in the generation and control of neuronal excitability. Genetic defects in ion channels are associated with several forms of human idiopathic epilepsies. These defects range from nonsense and missense point mutations to insertion, truncation and splice site mutations producing altered, non-functional or negative-dominant channel subunits. To date, 12 mutated gen...

It is estimated that at least 10 percent of HIV patients experience seizures. HIV positive patients are prone for convulsions as part of neurological complications of the disease or they may be having associated epilepsy. It can also be a complication of metabolic abnormalities very commonly seen in HIV positive patients. It can be the presenting symptom in a HIV positive patient. Intracranial ...

Ion channels play a central role in the generation and control of neuronal excitability. Genetic defects in ion channels are associated with several forms of human idiopathic epilepsies. These defects range from nonsense and missense point mutations to insertion, truncation and splice site mutations producing altered, non-functional or negative-dominant channel subunits. To date, 12 mutated gen...