In the present study, the effects of the acute and chronic oral administrations (po) of curcumin in the absence and presence of morphine and naloxone was investigated on the sensation of acute corneal pain in rats. Acute corneal pain was induced by the local application of hypertonic saline (5 M NaCl) on the corneal surface, and the number of eye wipes was then counted for 30 s. Subcutaneous (s...

PURPOSE Serum and saliva have recently been advocated as natural tear substitutes for intractable aqueous-deficient dry eyes, but the effects of these fluids on corneal epithelium have not been well characterized. A laboratory study was performed in a defined test model to compare the toxicity of natural and pharmaceutical tear substitutes and to identify potentially toxic factors in natural te...

PURPOSE The goal of this study was to determine whether a synthetic peptide, NC-1059, can modulate the corneal epithelium to increase the permeation of therapeutic agents across this barrier. METHODS An in vitro system employing transformed human corneal epithelial (THCE) cells was optimized for this study. Culture conditions were identified to promote formation of a confluent monolayer that ...

Corneal cross-linking has been described as an effective treatment to slow the progression of keratoconus. The standard protocol entails corneal epithelial removal allow diffusion riboflavin into stroma. Although, de-epithelization can generate risks or complications that transepithelial tries solve avoid. Different formulations were developed after verifying hydroxypropyl-?-cyclodextrin (HP?CD...

OBJECTIVES To propose a novel grading method for superficial punctate keratopathy (SPK) magnitude and to examine the quantitativeness of the method. METHODS In 351 eyes diagnosed as having dry eye syndrome, SPK was graded as follows. After fluorescein staining, the total sum of the area of SPK was graded from A0 through A3, and the density was graded from D0 through D3. The grading was repres...

Soft contact lenses are widely used for correction of refractive errors and in diseases related to corneal surface irregularities. In this case series we have used soft contact lenses in treatment of patients having bullous keratopathy, corneal ulcer, dry eye, trichiasis and corneal perforation. Soft contact lenses were found to be superior than conventional method of treatment and they have re...

PURPOSE Hydroxypropyl guar (HPG) and hyaluronic acid (HA) have been individually shown to improve dry eye symptoms. The purpose of this in vitro study was to assess the potential benefits of a new lubricant eye drop formulation containing the demulcents propylene glycol and polyethylene glycol and an HA/HPG dual polymer in models of the human corneal epithelium. METHODS Cultured human corneal...

Aims/background—The aim of this study was to assess quantitatively the eVectiveness of hyaluronan on corneal disruption in patients with dry eye.Corneal epithelial barrier function was evaluated by measuring fluorescein permeability using a slit-lamp fluorophotometer. Methods—11 patients with dry eye were assigned to this study. Hyaluronan ophthalmic solution (0.1% hyaluronic acid) was instille...