In congestive heart failure (CHF), diaphragm weakness is known to occur and is associated with myosin loss and activation of the ubiquitin-proteasome pathway. The effect of modulating proteasome activity on myosin loss and diaphragm function is unknown. The present study investigated the effect of in vivo proteasome inhibition on myosin loss and diaphragm function in CHF rats. Coronary artery l...

Main results 2 trials met the selection criteria: 1 trial compared the Prentif Cavity Rim Cervical Cap (Lamberts Ltd, Oxford, UK) with the Ortho diaphragm (Ortho Pharmaceutical Corporation, Raritan, NJ, USA) (n=1529, 6–24 mo follow up), and 1 trial compared the FemCap cervical cap (rubber manufactured by Hi-Tech Rubber, Anaheim, CA, USA) with the All-Flex diaphragm (Ortho) (n=841, 28 wk follow ...

We present a new model of turbulence spreading in magnetically confined plasma. A basic question in turbulence spreading is how to sustain finite amplitude fluctuations in a stable subcritical region, where linear dissipation of the turbulence is strong? The answer to this question relies on a consistent treatment of mesoscale temperature profile corrugation and microscale turbulence. We argue ...

Helium atom scattering (HAS) was used to study the antimony Sb(111) surface beyond the hard-wall model. HAS angular distributions and drift spectra show a number of selective adsorption resonance features, which correspond to five bound-state energies for He atoms trapped in the surface-averaged He-Sb(111) potential. As their best representation, a 9-3 potential with a depth of 4.4 ± 0.1 meV wa...

Hexagonal boron nitride (h-BN) adsorbed on metal surfaces shows great promise for applications in nanoscience. Depending on the nature of the substrate, effects such as an extended corrugation of the monolayer can be observed and utilized, e.g. for the patterning of adsorbed molecules. Here we present an in-depth computational study of the structural and electronic properties of a 6 nm Moiré pa...

In August 2009 the Sun illuminated Saturn's rings from almost exactly edge-on, revealing a subtle corrugation that extends across the entire C ring. This corrugation's amplitude is 2 to 20 meters and its wavelength is 30 to 80 kilometers. Radial trends in the corrugation's wavelength indicate that this structure--like a similar corrugation previously identified in the D ring--results from diffe...

During the past 10 years, intensive experimental research has focused on the effects of mechanical ventilation on the diaphragm. Whatever the animal species studied, all these studies have consistently shown that mechanical ventilation impaired diaphragm function, resulting in the so-called ventilatorinduced diaphragm dysfunction (VIDD) [1–9]. The development of this effect is rapid and worsens...

We investigated the dependence of electromechanical coupling and the piezoelectric response of a micromachined Pb(Zr₀.₅₂Ti₀.₄₈)O₃ (PZT) diaphragm on its curvature by observing the impedance spectrum and central deflection responses to a small AC voltage. The curvature of the diaphragm was controlled by applying air pressure to its back. We found that a depolarized flat diaphragm does not initia...