PURPOSE The purpose of this study was to obtain the description of the mandibular bone quality of male and female patients between 40-60 years old and their differences based on mandibular cortical bone thickness measured using Mental Index (MI). MATERIALS AND METHODS Forty digital panoramic radiographs, which consisted of twenty male and twenty female patients, 40-60 years old, were observed...

Takeuchi et al demonstrate an additional inhibitory effect on the progression of bone erosions in rheumatoid arthritis (RA) with the addition to methotrexate of an anti-receptor activator of nuclear factor kappa-B ligand (RANKL) antibody, denosumab, confirming results already reported 8 years ago by Cohen and colleagues. Insufficient inhibition of structural joint damage by diseasemodifying ant...

Low circulating IGF-I is associated with increased fracture risk. Conditional depletion of IGF-I produced in osteoblasts or osteocytes inhibits the bone anabolic effect of mechanical loading. Here, we determined the role of endocrine IGF-I for the osteogenic response to mechanical loading in young adult and old female mice with adult, liver-specific IGF-I inactivation (LI-IGF-I(-/-) mice, serum...

Bone fluoride concentration and bone mineral density (BMD) were evaluated in 51 female patients who had undergone hip arthroplasty due to proximal femur fracture. The hip fractures were divided into 42 neck and head fractures and 9 trochanteric fractures. BMD in the contralateral femoral neck and Ward triangle was determined by dual-energy X-ray absorptiometry measurement performed within 7 day...

Cylindrical specimens of bone measuring 15 mm in diameter were obtained from the lateral cortical layer of 10 pairs of femurs and tibias. A central hole 3.2 mm in diameter was drilled in each specimen. The hole was tapped, and a 4.5 mm cortical bone screw was inserted from the outer surface. The montage was submitted to push-out testing up to a complete strip of the bone threads. The cortical t...

In this study, we show that matrix dense cortical bone is the more potent compartment of bone than bone marrow as a stromal source for mesenchymal stem cells as isolated from adult rats. Lineage-depleted cortical bone-mesenchymal stem cells demonstrated >150-fold enrichment of colony forming unit-fibroblasts per cell incidence. compared to lineage-depleted bone marrow-mesenchymal stem cells, co...

The objectives of this study were to: 1) develop and validate a realistic FE model of the pelvis using subject-specific bone geometry, location-dependent cortical thickness and trabecular bone elastic modulus, and 2) assess the sensitivity of FE predictions to assumptions in both assumed and measured model inputs. A finite element model of a cadaveric pelvis was created using subject-specific C...

Major research carried out in modern dentistry and maxillofacial surgery is commonly focused on long-term stable results for implant rehabilitation of jaw defects deformities patients with bone soft tissue losses at the site planned implantation. Various osteoplastic materials, donor or patient’s own bone, tissue-engineering cellular products are common clinical medicine, since guided regenerat...

As cortical bone has a hierarchical structure, the macroscopic bone strength may be affected by the alterations of mineral crystal and collagen, which are main components of cortical bone. Limited studies focused on the time related alterations of these two components in osteoporosis, and their contributions to bone mechanics at tissue level and whole-bone level. Therefore, the purpose of this ...

Nonunion and secondary reduction loss complicate open distal femur fractures with bone loss. The authors hypothesized that locking plates decrease subsequent bone grafting yet maintain alignment and immediate postfixation radiographic features predict primary union. A retrospective chart/radiographic review was performed at a Level 1 university trauma center. Thirty-four adults with 36 open AO/...