It has been demonstrated that cortisone may enhance the development of metastases in both transplanted and spontaneous experimental tumors (2, 5, 7, 8). Whether or not this effect is the result of alterations in the primary tumor, the tumor bed, the sites of metastases, or is systemic is not clear. Furthermore, contradictory results have been reported concerning the effects of cortisone on the ...

The several and sometimes paradoxical effects of cortisone and its analogues on the course of a variety of infections may be duplicated in the relatively simple chick embryo-influenza virus model in which the interrelationships of a single obligate intracellular parasite and the cells of a single target organ (the allantoic entoderm) may be examined. Even in this simple system the influence of ...

AIM OF THE STUDY This study evaluated the effect of a new type of haemostatic--chemoprophylactic nasal packing (gel-tampon) on wound healing following the surgical removal of nasal polyps. These tampons are coated with a haemostatic hydrocolloid gel supported by a latex of microfibres and were soaked in solution of cortisone and antimycotic or antibiotic medicament. MATERIAL AND METHODS Seven...

A fast, sensitive, and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was validated and then the levels of cortisol and cortisone from sera of healthy adults were determined by the LC-MS/MS method. One hundred μ L of serum sample was directly extracted by adding 2 mL ethyl acetate, followed by chromatographic separation on a C18 column with a mobile phase consisting ...

Cortisone acetate, hydrocortisone, and hydrocortisone acetate depress the resistance of mice to pneumococcal and influenza viral infections, although hydrocortisone acetate is somewhat less effective than the free alcohol, when given subcutaneously. Pituitary adrenocorticotropin, even in highly purified form and in oil and beeswax, does not significantly alter the resistance of mice to these ex...

Cortisone and ACTH have been the focus of high hopes and grave fears and the centre 'of heated argument ever since their dramatic effect on rheumatoid arthritis was first announced by Philip Hench of the Mayo Clinic in I949. Because of the suffering caused by rheumatoid arthritis and the long history of frustration and failure to find a cure, they were hailed at first with little critical asses...