Background: Limb-girdle muscular dystrophy 2E (LGMD 2E), recently renamed as autosomal recessive limb-girdle dystrophy-4 (LGMDR4), is characterized by the lack of beta-sarcoglycan, normally expressed in skeletal muscles and cardiomyocytes. We hypothesized that progressive respiratory left ventricular (LV) failure LGMDR4 could be associated with age interrelated phenomena disease's natural histo...

Background: Systemic isotretinoin is a very effective medication for the treatment of acne, but it has some side effects. One of its side effects is musculoskeletal problems such as increased levels of creatine phosphokinase (CPK), myalgia, and serious muscle damage such as rhabdomyolysis. The aim of this study was to evaluate the incidence of myalgia and its relationship with the elevation of ...

Myocardial creatine phosphokinase (CPK) activity and myocardial blood flow (MFB, 15 +/- mu microspheres) were measured at 24 hours after ligation of the left anterior descending coronary artery in nine untreated anesthetized dogs, in eight dogs pretreated with intravenous propranolol 5 mg/kg and in eight which had both pretreatment as well as infusion of propranolol (1.25 mg/kg/hour) after occl...

For m = 3, 4, . . . , the polygonal numbers of order m are given by pm(n) = (m−2) ` n 2 ́ +n (n = 0, 1, 2, . . . ). For positive integers a, b, c and i, j, k > 3 with max{i, j, k} > 5, we call the triple (api, bpj , cpk) universal if for any n = 0, 1, 2, . . . there are nonnegative integers x, y, z such that n = api(x)+bpj(y)+cpk(z). We show that there are only 95 candidates for universal triple...

Renal cysts are central pathological features in a number of human congenital and acquired diseases, and produce significant morbidity and mortality. This review describes our laboratory's efforts to identify specific alterations in epithelial cell polarity and differentiation associated with renal tubular cyst formation and progressive enlargement. Studies in a murine model of human autosomal ...

Process capability indices (PCIs), Cp, Ca, Cpk, Cpm, and Cpmk have been developed in certain manufacturing industry as capability measures based on various criteria, including process consistency, process departure from a target, process yield, and process loss. It is noted in certain recent quality assurance and capability analysis works that the three indices, Cpk, Cpm, and Cpmk provide the s...

DIAGNOSTIC ENZYMOLOGY has grown exponentially since elevated serum amylase was first associated with pancreatitis in 19081 and Karmen, Wroblewski, LaDue, and their associates demonstrated in 1954 that SGOT* and LDH activity in serum increased following myocardial infarction.2 Following Markert's elucidation of the nature of LDH isoenzymes3 their importance in differential diagnosis was emphasiz...

background: vaginal sonograghy and serial -hcg are the most common diagnostic methods for ectopic pregnancy but about 50% of cases are initially misdiagnosed. in tubal pregnancy the zygote lies next to the muscular layer, and this invasion causes an increase in creatine phosphokinase (cpk) in blood. objective: assessment of cpk and its isoenzyme cpk-mb as a diagnostic marker for tubal pregnanc...