PURPOSE: Nonsyndromic cleft palate is a common craniofacial birth defect with an incidence of 1 in 700 live births. Recent studies have shown that connective tissue growth factor (CTGF/CCN2) has acted as a necessary downstream mediator of TGF-β-dependent mesenchymal stem cell proliferation in palatogenesis. In our laboratory, in CTGF/CCN2 knockout (KO) mice, we identified numerous craniofacial ...

PURPOSE: Nonsyndromic cleft palate is a common craniofacial birth defect with an incidence of 1 in 700 live births. Recent studies have shown that connective tissue growth factor (CTGF/CCN2) has acted as a necessary downstream mediator of TGF-β-dependent mesenchymal stem cell proliferation in palatogenesis. In our laboratory, in CTGF/CCN2 knockout (KO) mice, we identified numerous craniofacial ...

regardless of severity, earlier intervention to correct hearing loss in children improves speech development and conversational abilities. a cross-sectional study was performed on 230 neonates who were at risk of hearing loss in tehran university of medical sciences hospitals between september 2000 and february 2002. hearing was examined before the 3rd month by auditory brainstem responses (abr...

monosomy 21 is a rare chromosomal abnormality which is persented in mosaic or homogenous forms.the latter form which is very rare,is determined by intra uterin growth retardation)IUGR),failure to thrive (FTT),prominent craniofacial,skeletal deformities and differnt degrees of delay in psychomotor activities.we report an eight years old boy who was admitted in pediatric ward(hospital No 1 of Ker...

The replacement of teeth by implants is usually restricted to patients with completed craniofacial growth. Implant insertions in children or adolescents are circumvented due to several unfavorable potential effects including trauma to tooth germs, tooth eruption disorders and multidimensional restrictions of skeletal craniofacial growth. Moreover, the functional and esthetic results of the oral...

Craniofacial growth in 100 patients treated with the functional regulator of Fränkel for about 24 months was compared with craniofacial growth seen in a matched group of untreated persons with Class II malocclusion. Both conventional and geometric cephalometric analyses were used to evaluate the skeletal and dental adaptations. This study shows several clear effects of treatment in either of tw...