While there have been enormous strides in the understanding of Huntington's disease (HD) pathogenesis, treatment to slow or prevent disease progression remains elusive. We previously reported that dietary creatine supplementation significantly improves the clinical and neuropathological phenotype in transgenic HD mice lines starting at weaning, before clinical symptoms appear. We now report tha...

Fatigue sustained during short-term, highintensity exercise in humans is associated with the inability of skeletal muscle to maintain a high rate of anaerobic ATP production from phosphocreatine hydrolysis. Ingestion of creatine monohydrate at a rate of 20 g/d for 5–6 d was shown to increase the total creatine concentration of human skeletal muscle by 25 mmol/kg dry mass, some 30% of this in ph...

conclusions a short-term wbv exercise improves isotonic strength of the leg muscle and dynamic balance, while creatine supplementation with and without wbv training increases isometric strength of the leg muscle and mobility in elderly women. background a decline in neuromuscular function can cause a decrease in physical fitness in elderly women. objective the present study aimed at investigati...

OBJECTIVES To investigate the effects of a six-week plyometric training and creatine supplementation intervention on maximal-intensity and endurance performance in female soccer players during in-season training. DESIGN Randomized, double-blind, placebo-controlled trial. METHODS Young (age 22.9±2.5y) female players with similar training load and competitive background were assigned to a ply...

BACKGROUND The objective of this study was to determine the effects of creatine supplementation on liver biomarkers of oxidative stress in exercise-trained rats. METHODS Forty 90-day-old adult male Wistar rats were assigned to four groups for the eight-week experiment. Control group (C) rats received a balanced control diet; creatine control group (CCr) rats received a balanced diet supplemen...

While creatine has been known to man since 1835, when a French scientist reported finding this constitutent of meat, its presence in athletics as a performance enhancer is relatively new. Amid claims of increased power and strength, decreased performance time and increased muscle mass, creatine is being hailed as a true ergogenic aid. Creatinine is synthesised from the amino acids glycine, argi...

Guanidinoacetic acid (GAA) is an amino derivative and precursor for creatine which plays a significant role in energy metabolism. However, because of creatine’s instability during the manufacturing process cost, GAA has been explored as effective alternative to supplements. tested potential feed additive enhance utilization growth performance poultry swine industries. Moreover, combined with me...

Stroke leads to energy failure and subsequent neuronal cell loss. Creatine and phosphocreatine constitute a cellular energy buffering and transport system, and dietary creatine supplementation was shown to protect neurons in several models of neurodegeneration. Although creatine has recently been found to reduce infarct size after cerebral ischemia in mice, the mechanisms of neuroprotection rem...