A 65-year-old Thai male patient presented with significant weight loss and progressive renal dysfunction for 1 month. He was recently diagnosed allergic rhinitis multiple mononeuropathy. had elevated serum creatinine of 5 mg/dl (Baseline 1.2 mg/dl), high anti-myeloperoxidase titer IgG4 level. biopsy revealed extensive cellular fibrocellular crescents severe tubulointerstitial nephritis IgG4-pos...

Antibody-mediated glomerulonephritis, including that resulting from immune complexes, is an important cause of renal failure and is in need of more specific and effective treatment. Binding of antibody or immune complexes to Fc receptors activates intracellular signal transduction pathways, including spleen tyrosine kinase (Syk), leading to the production of inflammatory cytokines. We examined ...

In insects, abdominal appendages, also called prolegs, vary due to adaptive evolution. Mutations on prolegs within species provide insights to better understand the mechanisms underlying appendage development and diversity. In silkworm Bombyx mori, extra-crescents and degenerated abdominal legs (Edl) mutant, belonging to the E pseudoallele group, is a spontaneous mutation that adds crescents an...

Vestibular hair cells have a distinct planar cell polarity (PCP) manifest in the morphology of their stereocilia bundles and the asymmetric localization of their kinocilia. In the utricle and saccule the hair cells are arranged in an orderly array about an abrupt line of reversal that separates fields of cells with opposite polarity. We report that the putative PCP protein Prickle-like 2 (Pk2) ...

The coefficients in the confluent hypergeometric equation specify the Regge trajectories and the degeneracy of the angular momentum states. Bound states are associated with real angular momenta while resonances are characterized by complex angular momenta. With a centrifugal potential, the half-plane is tessellated by crescents. The addition of an electrostatic potential converts it into a hydr...