Crimean-Congo hemorrhagic fever (CCHF) has been reported from more than 30 countries around the world. Ribavirin is the only drug which has in vitro effect on CCHF virus. Although there is a debate on the clinical benefit of ribavirin, some experts from the endemic areas strongly recommend ribavirin in patients with CCHF based on in vitro activity and rare adverse events with shortterm use1. He...

background crimean-congo hemorrhagic fever (cchf) was a rare disease in iran before 1999. during the last 15 years, it has been reported from different provinces of iran, mostly from southeastern iran. objectives this study aimed to evaluate the factors associated with poor outcome in children and adolescents with cchf. patients and methods we studied all files of children (age < 19 years old) ...

conclusion we recommend that in outbreaks of cchf, care to prevent airborne transmission should be kept in mind. patient and method by a nosocomial transmission of crimean-congo hemorrhagic fever (cchf), a health care worker was infected in december 2008 due to a re-emerging outbreak of cchf in fars province, iran. after admission of probable cchf cases in a local hospital, one of the nurses co...

background: crimean-congo hemorrhagic fever virus (cchfv) belongs to genus nairovirus and family bunyaviridae. the main aim of this study was to investigate the extent of recombination in s-segment genome of cchfv in iran. methods: samples were isolated from iranian patients and those available in genbank, and analyzed by phyloge­netic and bootscan methods. results: through comparison of the ph...

Crimean-Congo hemorrhagic fever (CCHF) is a disease that poses a great threat to public health owing to its high mortality rate (30-70%), mode of transmission and geographic distribution. Here, we report on a nine years-old Sudanese boy from Southern Kordofan State who presented with Jaundice, high-grade fever, severe headache, abdominal pain and a history of hematemesis. The diagnosis of CCHF ...

Crimean-Congo hemorrhagic fever virus (CCHFV) is a tick-borne pathogen that causes high morbidity and mortality. Efficacy of vaccines and antivirals to treat human CCHFV infections remains limited and controversial. Research into pathology and underlying molecular mechanisms of CCHFV and other nairoviruses is limited. Significant progress has been made in our understanding of CCHFV replication ...

A patient with fever, and haemorrhagic symptoms was admitted to a hospital in Glasgow on 2 October 2012. Since he had returned from Afghanistan, serum samples were sent for diagnosis at the Rare and Imported Pathogens Laboratory, where a real-time reverse transcriptase-PCR diagnosis of Crimean – Congo haemorrhagic fever was made within 3 hrs after receipt of the sample. Hereafter the patient wa...

Four structural polypeptides of Hazara virus, an agent closely related to the Crimean-Congo haemorrhagic fever (C-CHF) viruses, were resolved by SDS-polyacrylamide gel electrophoresis. Three glycoproteins were identified (mol. wt. 84,000, 45,000 and 30,000) and were found to be associated with the virion envelope. A fourth polypeptide (mol. wt. 52,000) was non-glycosylated and associated with t...

Crimean-Congo haemorrhagic fever (CCHF) was diagnosed in a United Kingdom traveller who returned from Bulgaria in June 2014. The patient developed a moderately severe disease including fever, headaches and petechial rash. CCHF was diagnosed following identification of CCHF virus (CCHFV) RNA in a serum sample taken five days after symptom onset. Sequence analysis of the CCHFV genome showed that ...

The major arboviral diseases in mainland China include Japanese encephalitis, dengue fever, Crimean-Congo hemorrhagic fever (also known as Xinjiang hemorrhagic fever), and tick-borne encephalitis. These and other newly found arbovirus infections due to Banna virus and Tahyna virus contribute to a large and relatively neglected disease burden in China. Here we briefly review the literature regar...