Gene expression biomarkers can enable rapid assessment of physiological conditions in situ, providing a valuable tool for reef managers interested in linking organism physiology with large-scale climatic conditions. Here, we assessed the ability of quantitative PCR (qPCR)-based gene expression biomarkers to evaluate (i) the immediate cellular stress response (CSR) of Porites astreoides to incre...

Ewing sarcoma is the second most common primary malignant bone tumor in pediatrics after osteosarcoma, which mainly occurs children and adolescents aged 5-20 y. Crocin main active ingredient extracted from Crocus sativus has significant inhibitory effect on many cancer cells. Therefore, this study observed of crocin human its specific mechanism provided molecular theoretical basis for clinical ...

Pleurotus ostreatus better known as oyster mushroom is widely cultivated and consumed as food in Malaysia. The present study aims to assess the antioxidative potential and total phenolic content of P. ostreatus aqueous extract. The antioxidant activities were evaluated against DPPH and ABTS radical-scavenging activity, ferric-reducing antioxidant power (FRAP) and β-carotene-linoleate bleaching ...

Background: Saffron (Crocus sativus L.) is traditionally used as a spice for coloring and flavoring in cooking in some countries. One of the main component of saffron is Crocin. Recent researches have shown Crocin has various pharmacological effects. The aim of this study was to assess the effect of Crocin on the Pituitary-Gonadal Axis and Kiss-1 gene expression in hypothalamus and also ovarian...

OBJECTIVES Saffron is the stigma of Crocus sativus L., which has the potentials to play a role in the treatment of many diseases. Although many researches are now going on this precious spice, there are few data on saffron safety in human, especially in patients with chronic mental illnesses. This study aimed to evaluate the short-term safety and tolerability of both saffron and crocin (its maj...

objective(s): crocin is a constituent of saffron and has many biological functions. the present study aimed to investigate the effects of intraperitoneal (ip) injection of crocin on sciatic nerve regeneration in male wistar rats. materials and methods: fifty-four rats were divided into 9 groups: groups 1-4 (intact + normal saline and intact + crocin at doses of 5, 20 and 80 mg/kg, respectively)...

Endoplasmic reticulum (ER) stress is a homeostatic mechanism, which is used by cells to adapt to intercellular and intracellular changes. Moreover, ER stress is closely linked to inflammatory pathways. We hypothesized that ER stress is an integral component of neuroinflammation and contributes to the development of neurological diseases. In autopsied brain specimens from multiple sclerosis (MS)...

Beverage companies sometimes receive reports that cloudy fruit juices have developed a “metallic flavour” when they are exposed to light, which results in consumer complaints. These degradations have been shown to be caused by photooxidation, in which singlet oxygen played an essential role. In the present study, aqueous antioxidants, such as crocin, crocetin, and norbixin, have been investigat...

the essential oil of verbena officinalis growing in iran was extracted using hydro-distillationmethod and the antibacterial and antioxidant activities were evaluated. the antibacterial activity of the essentialoil against a gram-positive (s. aureus atcc25923) and gram negative (e. coli atcc 25922) were examined.the results obtained revealed that the essential oil exhibited variable levels of an...

Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chromatographically. Then, mice were orally administrated with geniposide (400 mg/kg b.w.), crocins (400 mg/kg b.w.), crocin-1 (400 mg/kg b.w.) and crocetin (14...