Recently, self-emulsifying drug delivery systems (SEDDS) have been developed as a method to deliver lipophilic drugs. Gelucire 44/14 is an excipient, from the lauroyl macrogolglycerides family, producing a fine oil-in-water emulsion when introduced into an aqueous phase under gentle agitation as SEDDS, improving thereby solubility of poorly water-soluble drugs and their bioavailability. The aim...

Charging mechanism of dust particles in a nonuniform discharge plasma under cryogenic environment is studied theoretically. The plasma density and temperature effects on dust grain charging are investigated with characteristic time scales of density variation and temperature relaxation in consideration. The charge of a dust grain, initially placed in a discharge plasma and cooled to cryogenic t...

We demonstrate a high-performance cryogenic amplifier based on a radio-frequency single-electrontransistor ~rf-SET!. The high charge sensitivity and large bandwidth of the rf-SET, along with low power dissipation, low capacitance and on-chip integrability, make it a good candidate for a general-purpose cryogenic amplifier for high impedance sources. We measure a large-gate rf-SET with an open-l...

Introduction Working cell banks (WCB’s) are commonly applied to initiate cell culture manufacturing campaigns for production of recombinant or therapeutic proteins. These campaigns typically begin with inoculation of cells previously cryopreserved in cryovials or ampoules. The baseline process proceeds from thaw of cell bank cryovials to scaling up through the seed train and inoculum train, fol...

  A refrigeration cycle is a chain of various pieces of equipment including compressors, condensers, evaporators, and expansion devices each of which takes on a particular thermodynamic process duty in the cycle that eventually results in the production of the required refrigeration. The results of optimized mixed refrigerant cycles (MRCs) in Part I show that the configuration of MRC is an eff...

Laser driven particle acceleration and measurements ofion energy loss in plasma largely rely on suitable targets toachieve good particle beam and plasma quality. Recent re-search results [2] indicate that cryogenic targets allow forvery high ion energies. Advantages of our cryogenic tar-gets include high purity at solid density in a self-supportedstructure as well as fit...

joule-thomson cooling systems are used in refrigeration processes such as cryogenic gas liquefaction. although extensive studies have been carried out by researchers, most of them include cryogenic heat exchangers and their associated fields. in the current study, an attempt was made to indicate the effect of using inappropriate operational conditions in a cryogenic joule-thomson cooling system...

â liquefied natural gas (lng) is the most economical way of transporting natural gas (ng) over long distances. liquefaction of ng by using vapor compression refrigeration system requires high operating and capital cost. due to lack of systematic design methods for multistage refrigeration cycles, the conventional approaches of determining optimal cycle configuration are mostly based on trial-an...