BACKGROUND There is a lack of high-quality evidence that advocates the use of corticosteroids for IgA nephropathy (IgAN) with minimal change-like lesions (also called IgAN with minimal change disease, MCD-IgAN). METHODS Twenty-seven biopsy-proven adult MCD-IgAN patients were enrolled. Daily single dose of 1 mg/kg (maximum 60 mg/day) prednisone was given until complete remission (CR), followed...

Background: Hypocholesterolemia possibly due to increased demand and uptake is correlated with elevated cancer risk mortality. However, hardly any current prognostic factor or model for chronic lymphocytic leukemia (CLL) established on reprogramed lipid metabolism, which suggests the importance of nutritional status tumor metabolism during leukemogenesis has been neglected. Our study aims inves...

CD44 molecule is a cell surface glycoprotein involved in many cell-cell and cell-matrix interactions. Circulating serum CD44 (s-CD44) levels have been found to change in parallel with response to therapy, but little is known about the predictive or prognostic significance of s-CD44. In the present study, we measured s-CD44 levels in sera taken before treatment from 194 patients with non-Hodgkin...

PURPOSE Ipilimumab (Ipi), a monoclonal antibody against cytotoxic T-lymphocyte antigen-4, has been shown to improve survival in patients with metastatic melanoma. In this single-institution study, we investigated the safety and efficacy of stereotactic radiosurgery (SRS) for patients with melanoma brain metastases (BMs) who also received Ipi. METHODS AND MATERIALS From 2005 to 2011, 46 patien...

Background The International Prognostic Index (IPI) has been a useful tool for predicting the prognosis of aggressive non-Hodgkin lymphoma in the last 20 years. Herein, we aimed to develop a new prognostic model for diffuse large B-cell lymphoma (DLBCL) in the rituximab era. Methods Between March 2004 and June 2012, patients with DLBCL treated with rituximab, cyclophosphamide, doxorubicin, vi...

Inflammatory periapical lesions are characterized by infiltration of different immune cell types, the functions which depend on an effective vascular network. This study aimed to evaluate mast cells density (MCD) in inflamatory odontogenic cysts capsules concerning microvascular (MVD), area (MVA), and perimeter (MVP), correlate such findings with type lesion, intensity inflammatory infiltrate, ...

BACKGROUND Multicentric Castleman disease (MCD) is a rare, systemic lymphoproliferative disorder driven by interleukin (IL)-6 overproduction. Siltuximab, an anti-IL-6 monoclonal antibody, has demonstrated durable tumor and symptomatic responses in a multinational, randomized, placebo-controlled study of MCD. METHODS This preplanned safety analysis was conducted to evaluate the long-term safet...